Research
Mechanical thrombectomy in patients with acute ischemic stroke: a cost-utility analysis
Xuanqian Xie, Anna Lambrinos, Brian Chan, Irfan A. Dhalla, Timo Krings, Leanne K. Casaubon, Cheemun Lum, Nancy Sikich, Aditya Bharatha, Vitor Mendes Pereira, Grant Stotts, Gustavo Saposnik, Christina O'Callaghan, Linda Kelloway and Michael D. Hill
June 16, 2016 4 (2) E316-E325; DOI: https://doi.org/10.9778/cmajo.20150088
Xuanqian Xie
Health Quality Ontario (Xie, Lambrinos, Chan, Dhalla, Sikich); Toronto Health Economics and Technology Assessment Collaborative (Xie), Leslie Dan Pharmacy, University of Toronto; Departments of Medical Imaging and Surgery (Krings, Pereira), University of Toronto; University Health Network - Toronto Western Hospital (Krings, Casaubon); Department of Medicine (Casaubon), Division of Neurology, University of Toronto; Stroke Outcomes Research Centre (Saposnik), St. Michael's Hospital, University of Toronto; Division of Neuroradiology (Bharatha), Department of Medical Imaging, St. Michael's Hospital, University of Toronto; Ontario Stroke Network (O'Callaghan, Kelloway), Toronto, Ont.; Ottawa Hospital Research Institute and Diagnostic Imaging - Interventional Neuroradiology (Lum), The Ottawa Hospital, University of Ottawa; Division of Neurology (Stotts), The Ottawa Hospital, Ottawa, Ont.; Department of Clinical Neurosciences (Hill), Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alta.
MScAnna Lambrinos
Health Quality Ontario (Xie, Lambrinos, Chan, Dhalla, Sikich); Toronto Health Economics and Technology Assessment Collaborative (Xie), Leslie Dan Pharmacy, University of Toronto; Departments of Medical Imaging and Surgery (Krings, Pereira), University of Toronto; University Health Network - Toronto Western Hospital (Krings, Casaubon); Department of Medicine (Casaubon), Division of Neurology, University of Toronto; Stroke Outcomes Research Centre (Saposnik), St. Michael's Hospital, University of Toronto; Division of Neuroradiology (Bharatha), Department of Medical Imaging, St. Michael's Hospital, University of Toronto; Ontario Stroke Network (O'Callaghan, Kelloway), Toronto, Ont.; Ottawa Hospital Research Institute and Diagnostic Imaging - Interventional Neuroradiology (Lum), The Ottawa Hospital, University of Ottawa; Division of Neurology (Stotts), The Ottawa Hospital, Ottawa, Ont.; Department of Clinical Neurosciences (Hill), Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alta.
MScBrian Chan
Health Quality Ontario (Xie, Lambrinos, Chan, Dhalla, Sikich); Toronto Health Economics and Technology Assessment Collaborative (Xie), Leslie Dan Pharmacy, University of Toronto; Departments of Medical Imaging and Surgery (Krings, Pereira), University of Toronto; University Health Network - Toronto Western Hospital (Krings, Casaubon); Department of Medicine (Casaubon), Division of Neurology, University of Toronto; Stroke Outcomes Research Centre (Saposnik), St. Michael's Hospital, University of Toronto; Division of Neuroradiology (Bharatha), Department of Medical Imaging, St. Michael's Hospital, University of Toronto; Ontario Stroke Network (O'Callaghan, Kelloway), Toronto, Ont.; Ottawa Hospital Research Institute and Diagnostic Imaging - Interventional Neuroradiology (Lum), The Ottawa Hospital, University of Ottawa; Division of Neurology (Stotts), The Ottawa Hospital, Ottawa, Ont.; Department of Clinical Neurosciences (Hill), Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alta.
MScIrfan A. Dhalla
Health Quality Ontario (Xie, Lambrinos, Chan, Dhalla, Sikich); Toronto Health Economics and Technology Assessment Collaborative (Xie), Leslie Dan Pharmacy, University of Toronto; Departments of Medical Imaging and Surgery (Krings, Pereira), University of Toronto; University Health Network - Toronto Western Hospital (Krings, Casaubon); Department of Medicine (Casaubon), Division of Neurology, University of Toronto; Stroke Outcomes Research Centre (Saposnik), St. Michael's Hospital, University of Toronto; Division of Neuroradiology (Bharatha), Department of Medical Imaging, St. Michael's Hospital, University of Toronto; Ontario Stroke Network (O'Callaghan, Kelloway), Toronto, Ont.; Ottawa Hospital Research Institute and Diagnostic Imaging - Interventional Neuroradiology (Lum), The Ottawa Hospital, University of Ottawa; Division of Neurology (Stotts), The Ottawa Hospital, Ottawa, Ont.; Department of Clinical Neurosciences (Hill), Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alta.
MDMScTimo Krings
Health Quality Ontario (Xie, Lambrinos, Chan, Dhalla, Sikich); Toronto Health Economics and Technology Assessment Collaborative (Xie), Leslie Dan Pharmacy, University of Toronto; Departments of Medical Imaging and Surgery (Krings, Pereira), University of Toronto; University Health Network - Toronto Western Hospital (Krings, Casaubon); Department of Medicine (Casaubon), Division of Neurology, University of Toronto; Stroke Outcomes Research Centre (Saposnik), St. Michael's Hospital, University of Toronto; Division of Neuroradiology (Bharatha), Department of Medical Imaging, St. Michael's Hospital, University of Toronto; Ontario Stroke Network (O'Callaghan, Kelloway), Toronto, Ont.; Ottawa Hospital Research Institute and Diagnostic Imaging - Interventional Neuroradiology (Lum), The Ottawa Hospital, University of Ottawa; Division of Neurology (Stotts), The Ottawa Hospital, Ottawa, Ont.; Department of Clinical Neurosciences (Hill), Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alta.
MDPhDLeanne K. Casaubon
Health Quality Ontario (Xie, Lambrinos, Chan, Dhalla, Sikich); Toronto Health Economics and Technology Assessment Collaborative (Xie), Leslie Dan Pharmacy, University of Toronto; Departments of Medical Imaging and Surgery (Krings, Pereira), University of Toronto; University Health Network - Toronto Western Hospital (Krings, Casaubon); Department of Medicine (Casaubon), Division of Neurology, University of Toronto; Stroke Outcomes Research Centre (Saposnik), St. Michael's Hospital, University of Toronto; Division of Neuroradiology (Bharatha), Department of Medical Imaging, St. Michael's Hospital, University of Toronto; Ontario Stroke Network (O'Callaghan, Kelloway), Toronto, Ont.; Ottawa Hospital Research Institute and Diagnostic Imaging - Interventional Neuroradiology (Lum), The Ottawa Hospital, University of Ottawa; Division of Neurology (Stotts), The Ottawa Hospital, Ottawa, Ont.; Department of Clinical Neurosciences (Hill), Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alta.
MDMScCheemun Lum
Health Quality Ontario (Xie, Lambrinos, Chan, Dhalla, Sikich); Toronto Health Economics and Technology Assessment Collaborative (Xie), Leslie Dan Pharmacy, University of Toronto; Departments of Medical Imaging and Surgery (Krings, Pereira), University of Toronto; University Health Network - Toronto Western Hospital (Krings, Casaubon); Department of Medicine (Casaubon), Division of Neurology, University of Toronto; Stroke Outcomes Research Centre (Saposnik), St. Michael's Hospital, University of Toronto; Division of Neuroradiology (Bharatha), Department of Medical Imaging, St. Michael's Hospital, University of Toronto; Ontario Stroke Network (O'Callaghan, Kelloway), Toronto, Ont.; Ottawa Hospital Research Institute and Diagnostic Imaging - Interventional Neuroradiology (Lum), The Ottawa Hospital, University of Ottawa; Division of Neurology (Stotts), The Ottawa Hospital, Ottawa, Ont.; Department of Clinical Neurosciences (Hill), Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alta.
MDNancy Sikich
Health Quality Ontario (Xie, Lambrinos, Chan, Dhalla, Sikich); Toronto Health Economics and Technology Assessment Collaborative (Xie), Leslie Dan Pharmacy, University of Toronto; Departments of Medical Imaging and Surgery (Krings, Pereira), University of Toronto; University Health Network - Toronto Western Hospital (Krings, Casaubon); Department of Medicine (Casaubon), Division of Neurology, University of Toronto; Stroke Outcomes Research Centre (Saposnik), St. Michael's Hospital, University of Toronto; Division of Neuroradiology (Bharatha), Department of Medical Imaging, St. Michael's Hospital, University of Toronto; Ontario Stroke Network (O'Callaghan, Kelloway), Toronto, Ont.; Ottawa Hospital Research Institute and Diagnostic Imaging - Interventional Neuroradiology (Lum), The Ottawa Hospital, University of Ottawa; Division of Neurology (Stotts), The Ottawa Hospital, Ottawa, Ont.; Department of Clinical Neurosciences (Hill), Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alta.
MScAditya Bharatha
Health Quality Ontario (Xie, Lambrinos, Chan, Dhalla, Sikich); Toronto Health Economics and Technology Assessment Collaborative (Xie), Leslie Dan Pharmacy, University of Toronto; Departments of Medical Imaging and Surgery (Krings, Pereira), University of Toronto; University Health Network - Toronto Western Hospital (Krings, Casaubon); Department of Medicine (Casaubon), Division of Neurology, University of Toronto; Stroke Outcomes Research Centre (Saposnik), St. Michael's Hospital, University of Toronto; Division of Neuroradiology (Bharatha), Department of Medical Imaging, St. Michael's Hospital, University of Toronto; Ontario Stroke Network (O'Callaghan, Kelloway), Toronto, Ont.; Ottawa Hospital Research Institute and Diagnostic Imaging - Interventional Neuroradiology (Lum), The Ottawa Hospital, University of Ottawa; Division of Neurology (Stotts), The Ottawa Hospital, Ottawa, Ont.; Department of Clinical Neurosciences (Hill), Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alta.
MDVitor Mendes Pereira
Health Quality Ontario (Xie, Lambrinos, Chan, Dhalla, Sikich); Toronto Health Economics and Technology Assessment Collaborative (Xie), Leslie Dan Pharmacy, University of Toronto; Departments of Medical Imaging and Surgery (Krings, Pereira), University of Toronto; University Health Network - Toronto Western Hospital (Krings, Casaubon); Department of Medicine (Casaubon), Division of Neurology, University of Toronto; Stroke Outcomes Research Centre (Saposnik), St. Michael's Hospital, University of Toronto; Division of Neuroradiology (Bharatha), Department of Medical Imaging, St. Michael's Hospital, University of Toronto; Ontario Stroke Network (O'Callaghan, Kelloway), Toronto, Ont.; Ottawa Hospital Research Institute and Diagnostic Imaging - Interventional Neuroradiology (Lum), The Ottawa Hospital, University of Ottawa; Division of Neurology (Stotts), The Ottawa Hospital, Ottawa, Ont.; Department of Clinical Neurosciences (Hill), Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alta.
MDMScGrant Stotts
Health Quality Ontario (Xie, Lambrinos, Chan, Dhalla, Sikich); Toronto Health Economics and Technology Assessment Collaborative (Xie), Leslie Dan Pharmacy, University of Toronto; Departments of Medical Imaging and Surgery (Krings, Pereira), University of Toronto; University Health Network - Toronto Western Hospital (Krings, Casaubon); Department of Medicine (Casaubon), Division of Neurology, University of Toronto; Stroke Outcomes Research Centre (Saposnik), St. Michael's Hospital, University of Toronto; Division of Neuroradiology (Bharatha), Department of Medical Imaging, St. Michael's Hospital, University of Toronto; Ontario Stroke Network (O'Callaghan, Kelloway), Toronto, Ont.; Ottawa Hospital Research Institute and Diagnostic Imaging - Interventional Neuroradiology (Lum), The Ottawa Hospital, University of Ottawa; Division of Neurology (Stotts), The Ottawa Hospital, Ottawa, Ont.; Department of Clinical Neurosciences (Hill), Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alta.
MDGustavo Saposnik
Health Quality Ontario (Xie, Lambrinos, Chan, Dhalla, Sikich); Toronto Health Economics and Technology Assessment Collaborative (Xie), Leslie Dan Pharmacy, University of Toronto; Departments of Medical Imaging and Surgery (Krings, Pereira), University of Toronto; University Health Network - Toronto Western Hospital (Krings, Casaubon); Department of Medicine (Casaubon), Division of Neurology, University of Toronto; Stroke Outcomes Research Centre (Saposnik), St. Michael's Hospital, University of Toronto; Division of Neuroradiology (Bharatha), Department of Medical Imaging, St. Michael's Hospital, University of Toronto; Ontario Stroke Network (O'Callaghan, Kelloway), Toronto, Ont.; Ottawa Hospital Research Institute and Diagnostic Imaging - Interventional Neuroradiology (Lum), The Ottawa Hospital, University of Ottawa; Division of Neurology (Stotts), The Ottawa Hospital, Ottawa, Ont.; Department of Clinical Neurosciences (Hill), Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alta.
MDChristina O'Callaghan
Health Quality Ontario (Xie, Lambrinos, Chan, Dhalla, Sikich); Toronto Health Economics and Technology Assessment Collaborative (Xie), Leslie Dan Pharmacy, University of Toronto; Departments of Medical Imaging and Surgery (Krings, Pereira), University of Toronto; University Health Network - Toronto Western Hospital (Krings, Casaubon); Department of Medicine (Casaubon), Division of Neurology, University of Toronto; Stroke Outcomes Research Centre (Saposnik), St. Michael's Hospital, University of Toronto; Division of Neuroradiology (Bharatha), Department of Medical Imaging, St. Michael's Hospital, University of Toronto; Ontario Stroke Network (O'Callaghan, Kelloway), Toronto, Ont.; Ottawa Hospital Research Institute and Diagnostic Imaging - Interventional Neuroradiology (Lum), The Ottawa Hospital, University of Ottawa; Division of Neurology (Stotts), The Ottawa Hospital, Ottawa, Ont.; Department of Clinical Neurosciences (Hill), Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alta.
BAppScLinda Kelloway
Health Quality Ontario (Xie, Lambrinos, Chan, Dhalla, Sikich); Toronto Health Economics and Technology Assessment Collaborative (Xie), Leslie Dan Pharmacy, University of Toronto; Departments of Medical Imaging and Surgery (Krings, Pereira), University of Toronto; University Health Network - Toronto Western Hospital (Krings, Casaubon); Department of Medicine (Casaubon), Division of Neurology, University of Toronto; Stroke Outcomes Research Centre (Saposnik), St. Michael's Hospital, University of Toronto; Division of Neuroradiology (Bharatha), Department of Medical Imaging, St. Michael's Hospital, University of Toronto; Ontario Stroke Network (O'Callaghan, Kelloway), Toronto, Ont.; Ottawa Hospital Research Institute and Diagnostic Imaging - Interventional Neuroradiology (Lum), The Ottawa Hospital, University of Ottawa; Division of Neurology (Stotts), The Ottawa Hospital, Ottawa, Ont.; Department of Clinical Neurosciences (Hill), Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alta.
RNMNMichael D. Hill
Health Quality Ontario (Xie, Lambrinos, Chan, Dhalla, Sikich); Toronto Health Economics and Technology Assessment Collaborative (Xie), Leslie Dan Pharmacy, University of Toronto; Departments of Medical Imaging and Surgery (Krings, Pereira), University of Toronto; University Health Network - Toronto Western Hospital (Krings, Casaubon); Department of Medicine (Casaubon), Division of Neurology, University of Toronto; Stroke Outcomes Research Centre (Saposnik), St. Michael's Hospital, University of Toronto; Division of Neuroradiology (Bharatha), Department of Medical Imaging, St. Michael's Hospital, University of Toronto; Ontario Stroke Network (O'Callaghan, Kelloway), Toronto, Ont.; Ottawa Hospital Research Institute and Diagnostic Imaging - Interventional Neuroradiology (Lum), The Ottawa Hospital, University of Ottawa; Division of Neurology (Stotts), The Ottawa Hospital, Ottawa, Ont.; Department of Clinical Neurosciences (Hill), Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alta.
MDMScData supplements
Online Appendices
Files in this Data Supplement:
- Appendix 1: Calibration of Natural History, Post-stroke Patients
- Appendix 2: Cost of Mechanical Thrombectomy Treatment
- Appendix 3: Validation of Economic Model
- Appendix 4: Incremental Cost Effectiveness Ratio (ICER) by Follow-up Time
- Appendix 5: Cost-Effectiveness Acceptability Curve
- Reviewer Comments
- Original Submission
- CHEERS Checklist
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Mechanical thrombectomy in patients with acute ischemic stroke: a cost-utility analysis
Xuanqian Xie, Anna Lambrinos, Brian Chan, Irfan A. Dhalla, Timo Krings, Leanne K. Casaubon, Cheemun Lum, Nancy Sikich, Aditya Bharatha, Vitor Mendes Pereira, Grant Stotts, Gustavo Saposnik, Christina O'Callaghan, Linda Kelloway, Michael D. Hill
Jun 2016, 4 (2) E316-E325; DOI: 10.9778/cmajo.20150088
Mechanical thrombectomy in patients with acute ischemic stroke: a cost-utility analysis
Xuanqian Xie, Anna Lambrinos, Brian Chan, Irfan A. Dhalla, Timo Krings, Leanne K. Casaubon, Cheemun Lum, Nancy Sikich, Aditya Bharatha, Vitor Mendes Pereira, Grant Stotts, Gustavo Saposnik, Christina O'Callaghan, Linda Kelloway, Michael D. Hill
Jun 2016, 4 (2) E316-E325; DOI: 10.9778/cmajo.20150088