BackgroundThere is conflicting evidence about the relationship between vitamin D deficiency
and depression, and a systematic assessment of the literature has not been available.…

Background Sensitivity analyses play a crucial role in assessing the robustness of the findings
or conclusions based on primary analyses of data in clinical trials. They are a critical way …

Background Cognitive behavioural therapy (CBT) is a widely used treatment for depression.
However, limited resource availability poses several barriers to patients seeking access to …

Context: Pancreatic α-cell hyperplasia (ACH) was once an esoteric pathological entity, but it
has become an important differential diagnosis of hyperglucagonemia after inactivating …

Background Reporting guidelines have been available for the past 17 years since the inception
of the Consolidated Standards of Reporting Trials statement in 1996. These guidelines …

Introduction: Despite its efficacy and widespread use, methadone maintenance treatment (MMT)
continues to be widely stigmatized. Reducing the stigma surrounding MMT will help …

BackgroundLight therapy is a known treatment for patients with seasonal affective disorder.
However, the efficacy of light therapy in treating patients with non-seasonal depression …

Background Whether used for pain management or recreation, opioids have a number of
adverse effects including hormonal imbalances. These imbalances have been reported to …

This narrative review aims to provide an overview of the impact of opioid dependence and
the contribution of genetics to opioid dependence. Epidemiological data demonstrate that …

Purpose Reporting guidelines (eg, Consolidated Standards of Reporting Trials [CONSORT]
statement) are intended to improve reporting standards and enhance the transparency and …