White matter hyperintensities (WMHs) are frequently seen on brain magnetic resonance
imaging scans of older people. Usually interpreted clinically as a surrogate for cerebral small …

BACKGROUND: Higher intake of omega-3 fatty acids (n-3 FAs) is associated with a reduced
risk of Alzheimer's disease (AD) and milder forms of cognitive impairment (eg cognitive …

It has been hypothesized that one mechanism through which physical activity provides
benefits to cognition and mood is via increasing brain‐derived neurotrophic factor ( BDNF ) …

BACKGROUND: Major depression occurs in 4.4% to 20% of the general population. Studies
suggest that major depression is accompanied by immune dysregulation and activation of …

BACKGROUND: Studies suggest that inflammation is involved in the neurodegenerative
cascade leading to Alzheimer's disease (AD) pathology and symptoms. This study sought to …

Background The mechanisms through which physical activity supports healthy brain
function remain to be elucidated. One hypothesis suggests that increased brain-derived …

Background Zinc is an essential micronutrient with diverse biological roles in cell growth,
apoptosis and metabolism, and in the regulation of endocrine, immune, and neuronal functions …

Mood disorders are marked by high rates of non-recovery, recurrence, and chronicity, which
are insufficiently addressed by current therapies. Several patho-etiological models have …

Bipolar Disorder (BD) has been conceptualized as both a cyclic and a progressive disorder.
Mechanisms involved in neuroprogression in BD remain largely unknown although several …

Type 2 diabetes mellitus (T2DM) is associated with depressive symptoms, and comorbid
depression in those with T2DM has been associated with adverse clinical profiles. Recognizing …