User profiles for Vikas Kapil

Vikas Kapil

Clinical Senior Lecturer in Clinical Pharmacology & Cardiovascular Medicine
Verified email at qmul.ac.uk
Cited by 6481

Immune boosting by B. 1.1. 529 (Omicron) depends on previous SARS-CoV-2 exposure

…, WYJ Lee, M Jensen, J Jones, M Jones, G Joy, V Kapil… - Science, 2022 - science.org
The Omicron, or Pango lineage B.1.1.529, variant of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) carries multiple spike mutations with high transmissibility and …

Inorganic nitrate supplementation lowers blood pressure in humans: role for nitrite-derived NO

V Kapil, AB Milsom, M Okorie, S Maleki-Toyserkani… - …, 2010 - Am Heart Assoc
Ingestion of dietary (inorganic) nitrate elevates circulating and tissue levels of nitrite via
bioconversion in the entero-salivary circulation. In addition, nitrite is a potent vasodilator in …

Dietary nitrate provides sustained blood pressure lowering in hypertensive patients: a randomized, phase 2, double-blind, placebo-controlled study

V Kapil, RS Khambata, A Robertson, MJ Caulfield… - …, 2015 - Am Heart Assoc
Single dose administration of dietary inorganic nitrate acutely reduces blood pressure (BP)
in normotensive healthy volunteers, via bioconversion to the vasodilator nitric oxide. We …

[HTML][HTML] Physiological role for nitrate-reducing oral bacteria in blood pressure control

V Kapil, SMA Haydar, V Pearl, JO Lundberg… - Free Radical Biology …, 2013 - Elsevier
Circulating nitrate (NO 3 − ), derived from dietary sources or endogenous nitric oxide
production, is extracted from blood by the salivary glands, accumulates in saliva, and is then …

Enhanced vasodilator activity of nitrite in hypertension: critical role for erythrocytic xanthine oxidoreductase and translational potential

SM Ghosh, V Kapil, I Fuentes-Calvo, KJ Bubb… - …, 2013 - Am Heart Assoc
Elevation of circulating nitrite (NO 2 − ) levels causes vasodilatation and lowers blood pressure
in healthy volunteers. Whether these effects and the underpinning mechanisms persist in …

[HTML][HTML] Accelerated resolution of inflammation underlies sex differences in inflammatory responses in humans

KS Rathod, V Kapil, S Velmurugan… - The Journal of …, 2023 - Am Soc Clin Investig
BACKGROUND. Cardiovascular disease occurs at lower incidence in premenopausal
females compared with age-matched males. This variation may be linked to sex differences in …

[HTML][HTML] Blood transcriptional biomarkers of acute viral infection for detection of pre-symptomatic SARS-CoV-2 infection: a nested, case-control diagnostic accuracy …

…, WYJ Lee, M Jensen, J Jones, M Jones, V Kapil… - The Lancet …, 2021 - thelancet.com
Background We hypothesised that host-response biomarkers of viral infections might
contribute to early identification of individuals infected with SARS-CoV-2, which is critical to …

Radiographic abnormalities and exposure to asbestos-contaminated vermiculite in the community of Libby, Montana, USA.

…, C Weis, M Spence, B Black, V Kapil - Environmental …, 2003 - ehp.niehs.nih.gov
Mining, handling, processing, and personal or commercial use of asbestos-contaminated
vermiculite have led to widespread contamination of the Libby, Montana, area. We initiated a …

[HTML][HTML] Antiplatelet effects of dietary nitrate in healthy volunteers: involvement of cGMP and influence of sex

S Velmurugan, V Kapil, SM Ghosh, S Davies… - Free Radical Biology …, 2013 - Elsevier
Ingestion of vegetables rich in inorganic nitrate has emerged as an effective method, via the
formation of a nitrite intermediate, for acutely elevating vascular NO levels. As such a …

[HTML][HTML] Assessment of traditional and improved stove use on household air pollution and personal exposures in rural western Kenya

…, R Nyagol, J Muoki, L de Beer, M Sage, V Kapil - Environment …, 2017 - Elsevier
Background Over 40% of the world's population relies on solid fuels for heating and cooking.
Use of improved biomass cookstoves (ICS) has the potential to reduce household air …