Coronavirus disease 2019 (COVID-19) can cause deadly healthcare-associated outbreaks.
In a major London teaching hospital, 66 of 435 (15%) COVID-19 inpatient cases between 2 …

Background The West African outbreak of Ebola virus disease has caused more than 8500
deaths. A vaccine could contribute to outbreak control in the region. We assessed a …

Background Cases of human monkeypox are rarely seen outside of west and central Africa.
There are few data regarding viral kinetics or the duration of viral shedding and no licensed …

Background Few data exist on the comparative safety and immunogenicity of different
COVID-19 vaccines given as a third (booster) dose. To generate data to optimise selection of …

Background Use of heterologous prime-boost COVID-19 vaccine schedules could facilitate
mass COVID-19 immunisation. However, we have previously reported that heterologous …

Background Emergence of variants with specific mutations in key epitopes in the spike
protein of SARS-CoV-2 raises concerns pertinent to mass vaccination campaigns and use of …

Most reported cases of human monkeypox occur in Central and West Africa, where the
causing virus is endemic. We describe the identification and public health response to an …

Background A subset of patients with severe COVID-19 develop a hyperinflammatory
syndrome, which might contribute to morbidity and mortality. This study explores a specific …

Since its first identification in Scotland, over 1,000 cases of unexplained paediatric hepatitis
in children have been reported worldwide, including 278 cases in the UK 1 . Here we report …

Background Some high-income countries have deployed fourth doses of COVID-19 vaccines,
but the clinical need, effectiveness, timing, and dose of a fourth dose remain uncertain. We …