Presented here is a genome sequence of an individual human. It was produced from ∼32
million random DNA fragments, sequenced by Sanger dideoxy technology and assembled …

We have synthesized a 582,970–base pair Mycoplasma genitalium genome. This synthetic
genome, named M. genitalium JCVI-1.0, contains all the genes of wild-type M. genitalium …

Background Next generation sequencing (NGS) platforms are currently being utilized for
targeted sequencing of candidate genes or genomic intervals to perform sequence-based …

Most RNA viruses lack the mechanisms to recognize and correct mutations that arise during
genome replication, resulting in quasispecies diversity that is required for pathogenesis and …

Since only a small fraction of environmental bacteria are amenable to laboratory culture,
there is great interest in genomic sequencing directly from single cells. Sufficient DNA for …

Background Multiple Displacement Amplification (MDA) is a method used for amplifying
limiting DNA sources. The high molecular weight amplified DNA is ideal for DNA library …

There is much interest in characterizing the variation in a human individual, because this
may elucidate what contributes significantly to a person's phenotype, thereby enabling …

OBJECTIVE: In recent years the consumption of alcohol mixed with energy drinks (AmED)
has become popular in young adults in North America. There have been few studies into the …

Selection biases may lead to systematic overestimate of protective effects from ‘moderate’
alcohol consumption. Overall, most sources of selection bias favor low‐volume drinkers in …

Influenza A virus is characterized by high genetic diversity 1 , 2 , 3 . However, most of what
is known about influenza evolution has come from consensus sequences sampled at the …