It is clear from the preceding overview of histamine receptor pharmacology that research into
the pharmacology of histamine receptors is at an exciting stage of development. The rapid …

The economic viability of the modern day mine is highly dependent upon careful planning
and management. Declining trends in average ore grades, increasing mining costs and …

Vascular endothelial growth factor-A (VEGF-A) is a key mediator of angiogenesis, signalling
via the class IV tyrosine kinase receptor family of VEGF Receptors (VEGFRs). Although …

… In this article Lisa Selbie and Stephen Hill review some of the evidence for these synergistic
interactions and suggest that they may have an important role in fine-tuning signals from …

Background: Docosahexaenoic acid (DHA) is important for brain function, and its status is
dependent on dietary intakes. Therefore, individuals who consume diets low in omega-3 (n-3) …

To realize the full scientific and clinical potential of human embryonic stem cell (hESC)-cardiomyocytes,
strategies to overcome the high degree of heterogeneity of differentiated …

The G‐protein‐coupled receptor (GPCR) family represents the largest and most versatile
group of cell surface receptors. Drugs active at these receptors have therapeutic actions across …

Bioluminescence resonance energy transfer (BRET) is a well-established method for
investigating protein-protein interactions. Here we present a BRET approach to monitor ligand …

A systematic review was undertaken to examine the evidence for B-type natriuretic peptides
(BNP and NT-proBNP) as independent predictors of mortality, morbidity, or combined …

β-Blockers have beneficial effects in heart failure, although the underlying mechanism is
unknown. β 2 -Adrenoceptors, however, are proportionally higher in the failing human heart. …