Development of a unilaterally-lesioned 6-OHDA mouse model of Parkinson's disease
SL Thiele, R Warre, JE Nash - JoVE (Journal of Visualized Experiments), 2012 - jove.com
The unilaterally lesioned 6-hyroxydopamine (6-OHDA)-lesioned rat model of Parkinson's
disease (PD) has proved to be invaluable in advancing our understanding of the mechanisms …
disease (PD) has proved to be invaluable in advancing our understanding of the mechanisms …
Selective loss of bi-directional synaptic plasticity in the direct and indirect striatal output pathways accompanies generation of parkinsonism and l-DOPA induced …
SL Thiele, B Chen, C Lo, TS Gertler, R Warre… - Neurobiology of …, 2014 - Elsevier
Parkinsonian symptoms arise due to over-activity of the indirect striatal output pathway, and
under-activity of the direct striatal output pathway. l-DOPA-induced dyskinesia (LID) is …
under-activity of the direct striatal output pathway. l-DOPA-induced dyskinesia (LID) is …
Sirtuin 3 rescues neurons through the stabilisation of mitochondrial biogenetics in the virally-expressing mutant α-synuclein rat model of parkinsonism
…, JHM Barber, Z Najarali, MH Khan, SL Thiele… - Neurobiology of …, 2017 - Elsevier
Parkinson's disease (PD) is a neurodegenerative movement disorder, which affects
approximately 1–2% of the population over 60 years of age. Current treatments for PD are …
approximately 1–2% of the population over 60 years of age. Current treatments for PD are …
Altered function of glutamatergic cortico-striatal synapses causes output pathway abnormalities in a chronic model of parkinsonism
R Warre, S Thiele, S Talwar, M Kamal… - Neurobiology of …, 2011 - Elsevier
OBJECTIVE: In Parkinson's disease, chronic striatal dopamine depletion results in over-activity
and under-activity of the indirect and direct striatal output pathways respectively. In this …
and under-activity of the indirect and direct striatal output pathways respectively. In this …
Epidemiology and liver transplantation burden of primary biliary cholangitis: a retrospective cohort study
…, A Mason, KM Peltekian, H Shah, S Thiele… - … Open Access Journal, 2018 - cmajopen.ca
Background: There is a wealth of data documenting the epidemiology of primary biliary
cholangitis (PBC) globally; however, the epidemiology of PBC has not been as well studied in …
cholangitis (PBC) globally; however, the epidemiology of PBC has not been as well studied in …
A novel MDMA analogue, UWA‐101, that lacks psychoactivity and cytotoxicity, enhances l‐DOPA benefit in parkinsonian primates
…, Z Millar, P Huot, K Wagg, S Thiele… - The FASEB …, 2012 - Wiley Online Library
Treatment of Parkinson's disease with dopaminergic agents, such as l‐DOPA, is frequently
compromised by disabling side effects, particularly dyskinesia and a shortening in duration of …
compromised by disabling side effects, particularly dyskinesia and a shortening in duration of …
Generation of a model of L-DOPA-induced dyskinesia in two different mouse strains
SL Thiele, R Warre, CS Khademullah, N Fahana… - Journal of neuroscience …, 2011 - Elsevier
Prolonged use of the dopamine precursor l-DOPA for the treatment of Parkinson's disease
commonly results in abnormal involuntary movements, which are termed l-DOPA-induced …
commonly results in abnormal involuntary movements, which are termed l-DOPA-induced …
Redesigning the designer drug ecstasy: non-psychoactive MDMA analogues exhibiting Burkitt's lymphoma cytotoxicity
…, ZA Millar, D Tindiglia, P Huot, T Johnston, S Thiele… - …, 2010 - pubs.rsc.org
Burkitt's lymphoma (BL) is a particularly aggressive cancer that primarily affects African
children. Unfortunately, effective and affordable treatment is out of reach of most of the afflicted. …
children. Unfortunately, effective and affordable treatment is out of reach of most of the afflicted. …
Chemical Synapses
S Thiele, J Nash - eLS - Wiley Online Library
Chemical synapses are among the most elaborate junctions existing between two cells,
enabling communication between neurons through chemical neurotransmission within …
enabling communication between neurons through chemical neurotransmission within …
[BOOK][B] Striatal mechanisms mediating parkinsonism and L-DOPA-induced dyskinesia: Contribution of the direct-and indirect-output pathways
SL Thiele - 2014 - search.proquest.com
L-DOPA (L-3, 4-dihydroxyphenylanalnine) therapy is indispensible in the treatment of
Parkinson's disease (PD) motor symptoms, but the use of these drugs is plagued by the …
Parkinson's disease (PD) motor symptoms, but the use of these drugs is plagued by the …