Objective Over the past decades, there have been significant efforts in the United States to
improve pharmaceutical labeling pertaining to pregnancy. The goal of this study was to …

Objectives The aims of this study were to develop a population pharmacokinetic model for
intravenous paracetamol in preterm and term neonates and to assess the generalizability of …

Introduction: Paracetamol is the most commonly used antipyretic and analgesic in pregnancy.
It is also increasingly used off-label in the neonatal intensive care unit. Despite the …

Objective: In view of the recent US Food and Drug Administration’s warning against the use
of sildenafil in pediatric patients, we aimed to provide an updated overview of the dosing and …

Objectives This study aimed to model the population pharmacokinetics of intravenous
paracetamol and its major metabolites in neonates and to identify influential patient characteristics…

Background In neonates, uncontrolled pain and opioid exposure are both correlated with
short- and long-term adverse events. Therefore, managing pain using opioid-sparing …

Background Paracetamol is commonly used for analgesia and patent ductus arteriosus (PDA)
treatment in preterm infants. We aimed to evaluate early neurodevelopmental outcomes of …

Background Milrinone use in the neonatal intensive care unit has increased over the last 10
years despite a paucity of published safety data in infants. We sought to determine the safety …

Introduction: Oral ibuprofen is more effective than intravenous (IV) ibuprofen for closure of a
patent ductus arteriosus (PDA). This study explored whether higher concentrations of the …

Background: Topical nitroglycerin (TNG) ointment has been used for almost 3 decades to treat
neonatal peripheral tissue ischemia, but this product is now no longer being produced by …