2-Hour accelerated diagnostic protocol to assess patients with chest pain symptoms using contemporary troponins as the only biomarker: the ADAPT trial

M Than, L Cullen, S Aldous, WA Parsonage… - Journal of the American …, 2012 - jacc.org
Objectives : The purpose of this study was to determine whether a new accelerated diagnostic
protocol (ADP) for possible cardiac chest pain could identify low-risk patients suitable for …

A 2-h diagnostic protocol to assess patients with chest pain symptoms in the Asia-Pacific region (ASPECT): a prospective observational validation study

M Than, L Cullen, CM Reid, SH Lim, S Aldous… - The Lancet, 2011 - thelancet.com
Background Patients with chest pain contribute substantially to emergency department
attendances, lengthy hospital stay, and inpatient admissions. A reliable, reproducible, and fast …

Validation of high-sensitivity troponin I in a 2-hour diagnostic strategy to assess 30-day outcomes in emergency department patients with possible acute coronary …

…, JH Greenslade, R Twerenbold, S Aldous… - Journal of the American …, 2013 - jacc.org
Objectives : The study objective was to validate a new high-sensitivity troponin I (hs-TnI)
assay in a clinical protocol for assessing patients who present to the emergency department …

Development and validation of the E mergency D epartment A ssessment of C hest pain S core and 2 h accelerated diagnostic protocol

…, J Doust, P Glasziou, J Kline, S Aldous… - Emergency Medicine …, 2014 - Wiley Online Library
Objective Risk scores and accelerated diagnostic protocols can identify chest pain patients
with low risk of major adverse cardiac event who could be discharged early from the ED , …

Rapid rule-out of acute myocardial infarction with a single high-sensitivity cardiac troponin T measurement below the limit of detection: a collaborative meta-analysis

JW Pickering, MP Than, L Cullen, S Aldous… - Annals of internal …, 2017 - acpjournals.org
This article has been corrected. The original version (PDF) is appended to this article as a
Supplement . Background: High-sensitivity assays for cardiac troponin T (hs-cTnT) are …

The HEART score for the assessment of patients with chest pain in the emergency department: a multinational validation study

…, J Greenslade, W Parsonage, S Aldous… - Critical pathways in …, 2013 - journals.lww.com
Objective: The HEART score for the early risk stratification of patients presenting to the
emergency department with chest pain contains 5 elements: history, electrocardiogram, age, risk …

A 2-hour diagnostic protocol for possible cardiac chest pain in the emergency department: a randomized clinical trial

M Than, S Aldous, SJ Lord, S Goodacre… - JAMA internal …, 2014 - jamanetwork.com
Importance Patients with chest pain represent a high health care burden, but it may be
possible to identify a patient group with a low short-term risk of adverse cardiac events who are …

Cardiac biomarkers in acute myocardial infarction

SJ Aldous - International journal of cardiology, 2013 - Elsevier
Each year, a large number of patients are seen in the Emergency Department with presentations
necessitating investigation for possible acute myocardial infarction. Patients can be …

[HTML][HTML] Effectiveness of EDACS versus ADAPT accelerated diagnostic pathways for chest pain: a pragmatic randomized controlled trial embedded within practice

MP Than, JW Pickering, SJ Aldous, L Cullen… - Annals of emergency …, 2016 - Elsevier
Study objective A 2-hour accelerated diagnostic pathway based on the Thrombolysis in
Myocardial Infarction score, ECG, and troponin measures (ADAPT-ADP) increased early …

Assessment of the European Society of Cardiology 0-hour/1-hour algorithm to rule-out and rule-in acute myocardial infarction

…, L Cullen, D Flaws, W Parsonage, S Aldous… - Circulation, 2016 - Am Heart Assoc
Background: The new European Society of Cardiology guidelines to rule-in and rule-out
acute myocardial infarction (AMI) in the emergency department include a rapid assessment …