Adipocytes have been suggested to be immunologically active, but their role in host defense
is unclear. We observed rapid proliferation of preadipocytes and expansion of the dermal …

Decades of work have elucidated cytokine signalling and transcriptional pathways that control
T cell differentiation and have led the way to targeted biologic therapies that are effective …

Appropriate use and interpretation of serological tests for assessments of severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) exposure, infection and potential immunity …

Appropriate use and interpretation of serological tests for assessments of SARS-CoV-2
exposure, infection and potential immunity require accurate assay performance data. We …

Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can
be detected indirectly by measuring the host immune response. For some viruses, antibody …

Age-associated insulin resistance (IR) and obesity-associated IR are two physiologically
distinct forms of adult-onset diabetes. While macrophage-driven inflammation is a core driver of …

Given the limited availability of serological testing to date, the seroprevalence of SARS-CoV-2-specific
antibodies in different populations has remained unclear. Here, we report very …

The efficacy of adoptive T cell therapies for cancer treatment can be limited by suppressive
signals from both extrinsic factors and intrinsic inhibitory checkpoints 1 , 2 . Targeted gene …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes coronavirus
disease-19 (COVID-19), has emerged as the cause of a global pandemic. We used RNA …

Patients with MLLr B-ALL have poor prognoses despite recent immunotherapy advances.
Here, surface proteomics identifies CD72 as being enriched on MLLr B-ALL but also widely …