The free radical theory of aging postulates that the production of intracellular reactive oxygen
species is the major determinant of life span. Numerous cell culture, invertebrate, and …

In lower organisms, increased expression of the NAD-dependent deacetylase Sir2
augments lifespan. The mechanism through which this life extension is mediated remains …

Genetic determinants of longevity include the forkhead-related transcription factor DAF-16
in the worm Caenorhabditis elegansand the p66shc locus in mice. We demonstrate …

Nutrient availability regulates life-span in a wide range of organisms. We demonstrate that
in mammalian cells, acute nutrient withdrawal simultaneously augments expression of the …

Background and Purpose— The Middle Cerebral Artery Embolism Local Fibrinolytic
Intervention Trial (MELT) Japan was organized to determine the safety and clinical efficacy of …

… Overexpression of E2F1 induces premature S-phase entry and often results in apoptosis
11,12 . Similarly to p53, E2F1 is stabilized and activated by DNA damage 13 . Therefore, we …

Leakage of mitochondrial oxidants contributes to a variety of harmful conditions ranging
from neurodegenerative diseases to cellular senescence. We describe here, however, a …

Our current understanding of the pathogenesis of sepsis suggests that bacteria as well as
bacterial-derived products activate an uncontrolled network of host-derived mediators such as …

p38, a subfamily of the mitogen-activated protein kinase, regulates gene expression in
response to various extracellular stimuli. The pyridinyl imidazoles like SB202190 are specific …

… Differences in variables among nontransgenic, placebo, and spironolactone groups were
compared by ANOVA, followed by Bartlett’s test for the homogeneity of variances. Variables …