Endothelium-derived NO plays a critical role in the regulation of cardiovascular function and
structure, as well as acting as a downstream mediator of the angiogenic response to …

OBJECTIVE: To assess the utility of hepcidin, a potent regulator of host defense and inflammation,
in the diagnosis of late-onset sepsis in very low birth weight infants. STUDY DESIGN: …

Surfactant protein B (SP-B) proprotein contains three saposin-like protein (SAPLIP) domains:
a SAPLIP domain corresponding to the mature SP-B peptide is essential for lung function …

Pulmonary surfactant is a lipoprotein complex that functions to reduce surface tension at the
air liquid interface in the alveolus of the mature lung. In late gestation glycogen-laden type II …

A computational model of myelin basic protein (MBP) has been constructed based on the
premise of a phylogenetically conserved β-sheet backbone and on electron microscopical …

Myelin basic protein (MBP) plays an integral role in the structure and function of the myelin
sheath. In humans and cattle, an 18.5-kDa isoform of MBP predominates and exists as a …

Pulmonary surfactant is a complex mixture of lipids and proteins that is essential for
postnatal function. Surfactant is synthesized in alveolar type II cells and stored as multi-bilayer …

Lung development is a highly regulated process directed by mesenchymal-epithelial
interactions, which coordinate the temporal and spatial expression of multiple regulatory factors …

CTP phosphocholine cytidylyltransferase (CCT) is a rate-determining enzyme in de novo
synthesis of phosphatidylcholine (PC). The lung requires a steady synthesis of PC for lung …

Spinal muscular atrophy (SMA) is a progressive neuromuscular disease caused by biallelic
pathogenic/likely pathogenic variants of the survival motor neuron 1 (SMN1) gene. Early …