This study was designed to examine the inflammatory process in the central and peripheral
airways of surgically resected lungs from asthmatic and nonasthmatic subjects. Lung …

Human respiratory syncytial virus (RSV) causes a large burden of disease worldwide 1 .
There is no effective vaccine or therapy, and the use of passive immunoprophylaxis with RSV-…

Interferon-α (IFN-α) is essential for antiviral immunity, but in the absence of matrix
metalloproteinase-12 (MMP-12) or IκBα (encoded by NFKBIA) we show that IFN-α is retained in the …

A substantial proportion of healthcare cost associated with asthma is attributable to exacerbations
of the disease. Within the airway, the epithelium forms the mucosal immune barrier, …

PURPOSE: We compared the prevalence and spectrum of common respiratory viruses
among patients with near-fatal asthma, acute exacerbations of asthma, or chronic obstructive …

Respiratory viruses exert a heavy toll of morbidity and mortality worldwide. Despite this
burden there are few specific treatments available for respiratory virus infections. Since many …

Primary ciliary dyskinesia (PCD) is a heterogeneous genetic condition. European and North
American diagnostic guidelines recommend transmission electron microscopy (TEM) as …

Respiratory diseases are the most frequent chronic illnesses in babies and children.
Although a vigorous innate immune system is critical for maintaining lung health, a balanced …

Alveolar macrophages (AM) play a pivotal role in host lung defense mechanisms. Respiratory
syncytial virus (RSV) stimulates secretion of proinflammatory cytokines in AM while it …

Enteropathogenic Escherichia coli (EPEC) belongs to a family of related bacterial pathogens,
including enterohemorrhagic Escherichia coli (EHEC) O157:H7 and other human and …