Alzheimer's disease (AD), the leading cause of dementia worldwide, is characterized by the
accumulation of the β-amyloid peptide (Aβ) within the brain along with hyperphosphorylated …

Mutations in Cu/Zn superoxide dismutase (SOD1) cause a subset of cases of familial
amyotrophic lateral sclerosis. Four lines of mice accumulating one of these mutant proteins (G37R) …

They selected references within their field of expertise and experience and graded the
references according to the GRADE system. 1 The selection of references for the guideline was …

Two β-secretases, BACE1 and BACE2, are involved in generation of Alzheimer's disease
Aβ peptides 1, 2, 3. We report that secretion of Aβ peptides (Aβ1–40/42 and Aβ11–40/42) is …

The generation of amyloid β-peptide (Aβ) by enzymatic cleavages of the β-amyloid precursor
protein (APP) has been at the center of Alzheimer’s disease (AD) research. While the basic …

Approximately 10% of cases of Alzheimer's disease are familial and associated with autosomal
dominant inheritance of mutations in genes encoding the amyloid precursor protein 1 , …

The GGGGCC (G 4 C 2 ) repeat expansion in a noncoding region of C9orf72 is the most
common cause of sporadic and familial forms of amyotrophic lateral sclerosis and …

Familial amyotrophic lateral sclerosis (FALS) has been linked to mutations in the homodimeric
enzyme Cu/Zn superoxide dismutase 1 (SOD1). Assay by transient expression in primate …

To the editor—A critical feature of Alzheimer disease (AD) is the deposition of plaque, which
contains high levels of amyloid-β (Aβ) peptides1. A small subset of AD patients carry the …

The β-amyloid (Aβ) peptide is the major constituent of amyloid plaques in Alzheimer's
disease (AD) brain and is likely to play a central role in the pathogenesis of this devastating …