Structure-based design of prefusion-stabilized SARS-CoV-2 spikes
The coronavirus disease 2019 (COVID-19) pandemic has led to accelerated efforts to develop
therapeutics and vaccines. A key target of these efforts is the spike (S) protein, which is …
therapeutics and vaccines. A key target of these efforts is the spike (S) protein, which is …
[PDF][PDF] Constructive social work
N Parton, P O'Byrne - Towards a new practice, 2000 - open.edu
Curiosity. To me it evokes ‘concern’; it evokes the care one takes for what exists and could
exist; a readiness to find strange what surrounds us; a certain relentlessness to break up our …
exist; a readiness to find strange what surrounds us; a certain relentlessness to break up our …
[BOOK][B] Assessment in social work
J Milner, S Myers, P O'Byrne - 2020 - books.google.com
Assessment is a core component of social work. Since first publication, Assessment in Social
Work has provided students and practitioners with a clear overview of the complex issues …
Work has provided students and practitioners with a clear overview of the complex issues …
[PDF][PDF] EGFR ligands differentially stabilize receptor dimers to specify signaling kinetics
Epidermal growth factor receptor (EGFR) regulates many crucial cellular programs, with seven
different activating ligands shaping cell signaling in distinct ways. Using crystallography …
different activating ligands shaping cell signaling in distinct ways. Using crystallography …
How IGF-1 activates its receptor
10.7554/eLife.03772.001 The type I insulin-like growth factor receptor (IGF1R) is involved in
growth and survival of normal and neoplastic cells. A ligand-dependent conformational …
growth and survival of normal and neoplastic cells. A ligand-dependent conformational …
[HTML][HTML] Canadian guideline on HIV pre-exposure prophylaxis and nonoccupational postexposure prophylaxis
Methods The guideline was developed by the Biomedical HIV Prevention Working Group of
the CIHR Canadian HIV Trials Network, with funding from the Canadian Institutes of Health …
the CIHR Canadian HIV Trials Network, with funding from the Canadian Institutes of Health …
Observing linked data dynamics
In this paper, we present the design and first results of the Dynamic Linked Data Observatory:
a long-term experiment to monitor the two-hop neighbourhood of a core set of eighty …
a long-term experiment to monitor the two-hop neighbourhood of a core set of eighty …
Expression of Genes in Cyanobacteria: Adaptation of Endogenous Plasmids as Platforms for High-Level Gene Expression in Synechococcus sp. PCC 7002
Synechococcus sp. PCC 7002 is an ideal model cyanobacterium for functional genomics
and biotechnological applications through metabolic engineering. A gene expression system …
and biotechnological applications through metabolic engineering. A gene expression system …
A single ligand is sufficient to activate EGFR dimers
Crystal structures of human epidermal growth factor receptor (EGFR) with bound ligand
revealed symmetric, doubly ligated receptor dimers thought to represent physiologically active …
revealed symmetric, doubly ligated receptor dimers thought to represent physiologically active …
The development of interactive online learning tools for the study of anatomy
PJ O'Byrne, A Patry, JA Carnegie - Medical Teacher, 2008 - Taylor & Francis
Background: The study of human anatomy is a core component of health science programs.
However large student enrolments and the content-packed curricula associated with these …
However large student enrolments and the content-packed curricula associated with these …
