Identification of protein–protein interactions often provides insight into protein function, and
many cellular processes are performed by stable protein complexes. We used tandem affinity …

A newly described coronavirus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2),
which is the causative agent of coronavirus disease 2019 (COVID-19), has …

Defining the functional relationships between proteins is critical for understanding virtually
all aspects of cell biology. Large-scale identification of protein complexes has provided one …

We present a strategy for generating and analyzing comprehensive genetic-interaction
maps, termed E-MAPs (epistatic miniarray profiles), comprising quantitative measures of …

We have developed an approach using Bayesian networks to predict protein-protein
interactions genome-wide in yeast. Our method naturally weights and combines into reliable …

The yeast histone deacetylase Rpd3 can be recruited to promoters to repress transcription
initiation. Biochemical, genetic, and gene-expression analyses show that Rpd3 exists in two …

Defining protein complexes is critical to virtually all aspects of cell biology. Two recent affinity
purification/mass spectrometry studies in Saccharomyces cerevisiae have vastly increased …

Methylation of histone proteins is one of their many modifications that affect chromatin structure
and regulate gene expression. Methylation of histone H3 on lysines 4 and 79, catalyzed …

The causative agent of the coronavirus disease 2019 (COVID-19) pandemic, severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), has infected millions and killed hundreds …

Set2 methylates Lys36 of histone H3. We show here that yeast Set2 copurifies with RNA
polymerase II (RNAPII). Chromatin immunoprecipitation analyses demonstrated that Set2 and …