[HTML][HTML] Targeting Rho GTPase signaling networks in cancer
NS Clayton, AJ Ridley - Frontiers in cell and developmental biology, 2020 - frontiersin.org
As key regulators of cytoskeletal dynamics, Rho GTPases coordinate a wide range of cellular
processes, including cell polarity, cell migration, and cell cycle progression. The adoption …
processes, including cell polarity, cell migration, and cell cycle progression. The adoption …
Canadian emergency physician psychological distress and burnout during the first 10 weeks of COVID‐19: A mixed‐methods study
Objectives The aim of this study was to report burnout time trends and describe the psychological
effects of working as a Canadian emergency physician during the first weeks of the …
effects of working as a Canadian emergency physician during the first weeks of the …
Immunohistochemistry in investigative and toxicologic pathology
KS Janardhan, H Jensen, NP Clayton… - Toxicologic …, 2018 - journals.sagepub.com
Immunohistochemistry (IHC) is a valuable tool in pathology. This review provides a brief
description of the technical aspects of IHC and a detailed discussion on the variables that affect …
description of the technical aspects of IHC and a detailed discussion on the variables that affect …
Abrogation of lupus nephritis in activation-induced deaminase-deficient MRL/lpr mice
C Jiang, J Foley, N Clayton, G Kissling… - The Journal of …, 2007 - journals.aai.org
We generated MRL/lpr mice deficient in activation-induced deaminase (AID). Because AID
is required for Ig hypermutation and class switch recombination, these mice lack …
is required for Ig hypermutation and class switch recombination, these mice lack …
Clinical chemistry score versus high-sensitivity cardiac troponin I and T tests alone to identify patients at low or high risk for myocardial infarction or death at …
BACKGROUND: Testing for high-sensitivity cardiac troponin (hs-cTn) may assist triage and
clinical decision-making in patients presenting to the emergency department with symptoms …
clinical decision-making in patients presenting to the emergency department with symptoms …
Rule-in and rule-out of myocardial infarction using cardiac troponin and glycemic biomarkers in patients with symptoms suggestive of acute coronary syndrome
C Shortt, J Ma, N Clayton, J Sherbino… - Clinical …, 2017 - academic.oup.com
BACKGROUND Early rule-in/rule-out of myocardial infarction (MI) in patients presenting to
the emergency department (ED) is important for patient care and resource allocation. Given …
the emergency department (ED) is important for patient care and resource allocation. Given …
[PDF][PDF] PHLDA1 mediates drug resistance in receptor tyrosine kinase-driven cancer
AE Fearon, EP Carter, NS Clayton, EH Wilkes… - Cell reports, 2018 - cell.com
Development of resistance causes failure of drugs targeting receptor tyrosine kinase (RTK)
networks and represents a critical challenge for precision medicine. Here, we show that …
networks and represents a critical challenge for precision medicine. Here, we show that …
[HTML][HTML] Assembly of nuclear dimers of PI3K regulatory subunits is regulated by the Cdc42-activated tyrosine kinase ACK
NS Clayton, M Fox, JJ Vicenté-Garcia… - Journal of Biological …, 2022 - ASBMB
Activated Cdc42-associated kinase (ACK) is an oncogenic nonreceptor tyrosine kinase
associated with poor prognosis in several human cancers. ACK promotes proliferation, in part by …
associated with poor prognosis in several human cancers. ACK promotes proliferation, in part by …
[HTML][HTML] Short‐term tetrabromobisphenol A exposure promotes fibrosis of human uterine fibroid cells in a 3D culture system through TGF‐beta signaling
J Liu, L Yu, L Castro, Y Yan, NP Clayton… - The FASEB …, 2022 - ncbi.nlm.nih.gov
Tetrabromobisphenol A (TBBPA), a derivative of BPA, is a ubiquitous environmental
contaminant with weak estrogenic properties. In women, uterine fibroids are highly prevalent …
contaminant with weak estrogenic properties. In women, uterine fibroids are highly prevalent …
Characterization of four new mouse cytochrome P450 enzymes of the CYP2J subfamily
…, J Cheng, FB Lih, TA Masinde, W Qu, NP Clayton… - Drug Metabolism and …, 2013 - ASPET
The cytochrome P450 superfamily encompasses a diverse group of enzymes that catalyze
the oxidation of various substrates. The mouse CYP2J subfamily includes members that have …
the oxidation of various substrates. The mouse CYP2J subfamily includes members that have …