[HTML][HTML] Rates of hyperkalemia after publication of the Randomized Aldactone Evaluation Study
DN Juurlink, MM Mamdani, DS Lee… - … England Journal of …, 2004 - Mass Medical Soc
Background The Randomized Aldactone Evaluation Study (RALES) demonstrated that
spironolactone significantly improves outcomes in patients with severe heart failure. Use of …
spironolactone significantly improves outcomes in patients with severe heart failure. Use of …
[HTML][HTML] A population-based study of the drug interaction between proton pump inhibitors and clopidogrel
Background: Most proton pump inhibitors inhibit the bioactivation of clopidogrel to its active
metabolite. The clinical significance of this drug interaction is unknown. Methods: We …
metabolite. The clinical significance of this drug interaction is unknown. Methods: We …
Long-term analgesic use after low-risk surgery: a retrospective cohort study
Background This study evaluated the risk of long-term analgesic use after low-risk surgery
in older adults not previously prescribed analgesics. Methods We conducted a retrospective …
in older adults not previously prescribed analgesics. Methods We conducted a retrospective …
Chronic dialysis and death among survivors of acute kidney injury requiring dialysis
Context Severe acute kidney injury among hospitalized patients often necessitates initiation
of short-term dialysis. Little is known about the long-term outcome of those who survive to …
of short-term dialysis. Little is known about the long-term outcome of those who survive to …
Opioid dose and drug-related mortality in patients with nonmalignant pain
Background Opioids are widely prescribed for chronic nonmalignant pain, often at doses
exceeding those recommended in clinical practice guidelines. However, the risk-benefit ratio of …
exceeding those recommended in clinical practice guidelines. However, the risk-benefit ratio of …
A comparison of propensity score methods: a case‐study estimating the effectiveness of post‐AMI statin use
PC Austin, MM Mamdani - Statistics in medicine, 2006 - Wiley Online Library
There is an increasing interest in the use of propensity score methods to estimate causal
effects in observational studies. However, recent systematic reviews have demonstrated that …
effects in observational studies. However, recent systematic reviews have demonstrated that …
Bisphosphonate use and the risk of subtrochanteric or femoral shaft fractures in older women
LY Park-Wyllie, MM Mamdani, DN Juurlink, GA Hawker… - Jama, 2011 - jamanetwork.com
Context Osteoporosis is associated with significant morbidity and mortality. Oral bisphosphonates
have become a mainstay of treatment, but concerns have emerged that long-term use …
have become a mainstay of treatment, but concerns have emerged that long-term use …
The burden of opioid-related mortality in the United States
Importance Opioid prescribing and overdose are leading public health problems in North
America, yet the precise public health burden has not been quantified. Objective To examine …
America, yet the precise public health burden has not been quantified. Objective To examine …
Risk of incident diabetes among patients treated with statins: population based study
…, X Camacho, DN Juurlink, BR Shah, MM Mamdani - Bmj, 2013 - bmj.com
Objective To examine the risk of new onset diabetes among patients treated with different
HMG-CoA reductase inhibitors (statins). Design Population based cohort study with time to …
HMG-CoA reductase inhibitors (statins). Design Population based cohort study with time to …
Prescribing of opioid analgesics and related mortality before and after the introduction of long-acting oxycodone
IA Dhalla, MM Mamdani, MLA Sivilotti, A Kopp… - Cmaj, 2009 - Can Med Assoc
Introduction: Opioid-related mortality appears to be increasing in Canada. We examined the
true extent of the problem and the impact of the introduction of long-acting oxycodone. …
true extent of the problem and the impact of the introduction of long-acting oxycodone. …