Illuminating the molecular mechanisms of tyrosine kinase inhibitor resistance for the FGFR1 gatekeeper mutation: the Achilles' heel of targeted therapy

CD Sohl, MR Ryan, BB Luo, KM Frey… - ACS chemical …, 2015 - ACS Publications
Human fibroblast growth factor receptors (FGFRs) 1–4 are a family of receptor tyrosine kinases
that can serve as drivers of tumorigenesis. In particular, FGFR1 gene amplification has …

Discovery, synthesis, and molecular pharmacology of selective positive allosteric modulators of the δ-opioid receptor

…, KE Livingston, M Canals, MR Ryan… - Journal of Medicinal …, 2015 - ACS Publications
Allosteric modulators of G protein-coupled receptors (GPCRs) have a number of potential
advantages compared to agonists or antagonists that bind to the orthosteric site of the receptor…

Team dynamics, clinical work satisfaction, and patient care coordination between primary care providers: a mixed methods study

H Song, M Ryan, S Tendulkar, J Fisher… - Health care …, 2017 - journals.lww.com
Background: Team-based care is essential for delivering high-quality, comprehensive, and
coordinated care. Despite considerable research about the effects of team-based care on …

Technologies of trust in epidemic response: openness, reflexivity and accountability during the 2014–2016 Ebola outbreak in West Africa

MJ Ryan, T Giles-Vernick, JE Graham - BMJ Global Health, 2019 - gh.bmj.com
Trust is an essential component of successful cooperative endeavours. The global health
response to the 2014–2016 West Africa Ebola outbreak confronted historically tenuous …

Technology, professional practice, and ethics: Survey findings and implications.

…, T Buchanan, BM Ellens, MK Ryan - … : Research and Practice, 1999 - psycnet.apa.org
If a psychologist loses treatment records because of a computer failure, is it an ethical
violation? The widespread growth of technology has outpaced the development of ethical …

The FGFR1 V561M gatekeeper mutation drives AZD4547 resistance through STAT3 activation and EMT

MR Ryan, CD Sohl, BB Luo, KS Anderson - Molecular Cancer Research, 2019 - AACR
The V561M FGFR1 gatekeeper mutation leads to devastating drug resistance through
activation of STAT3 and the epithelial–mesenchymal transition; this study demonstrates that …

Breaking bread with the dead

E Stover, M Ryan - Historical Archaeology, 2001 - Springer
The establishment of two international ad hoc tribunals for Rwanda and the former
Yugoslavia, and the creation of an International Criminal Court within the next five years, has …

Evidence of enhanced reproductive performance and lack‐of‐fitness costs among soybean aphids, Aphis glycines, with varying levels of pyrethroid resistance

…, BS Coates, EW Hodgson, M Ryan… - Pest Management …, 2022 - Wiley Online Library
BACKGROUND Foliar application of insecticides is the main strategy to manage soybean
aphid, Aphis glycines (Hemiptera: Aphididae), in the northcentral United States. …

[HTML][HTML] Family presence in Canadian PICUs during the COVID-19 pandemic: a mixed-methods environmental scan of policy and practice

JR Foster, LA Lee, JA Seabrook, M Ryan… - … Open Access Journal, 2022 - cmajopen.ca
Background: Despite their broad commitment to family-centred care, children’s hospitals
and associated pediatric intensive care units (PICUs) restricted family presence during the …

[HTML][HTML] MYB fusions and CD markers as tools for authentication and purification of cancer stem cells from salivary adenoid cystic carcinoma

A Panaccione, Y Zhang, M Ryan, CA Moskaluk… - Stem cell …, 2017 - Elsevier
Cancer stem cells (CSC) are considered the major cause of aggressive tumor behavior,
recurrence, metastases, and resistance to radiation, making them an attractive therapeutic target…