… in epigenetic regulatory genes and demonstrated marked intra-tumour heterogeneity, which
… However, over the past decade, marked advances in the treatment of metastatic RCC have …

Background: The magnitude of risk conferred by the interaction between tobacco and alcohol
use on the risk of head and neck cancers is not clear because studies have used various …

Background The benefits of endoscopic testing for colorectal-cancer screening are uncertain.
We evaluated the effect of screening with flexible sigmoidoscopy on colorectal-cancer …

The primary circulating form of vitamin D, 25-hydroxy-vitamin D [25(OH)D], is associated with
multiple medical outcomes, including rickets, osteoporosis, multiple sclerosis and cancer. …

Objective A history of periodontal disease and the presence of circulating antibodies to selected
oral pathogens have been associated with increased risk of pancreatic cancer; however…

Background Sexual contact may be the means by which head and neck cancer patients are
exposed to human papillomavirus (HPV). Methods We undertook a pooled analysis of four …

We conducted a multi-stage, genome-wide association study of bladder cancer with a
primary scan of 591,637 SNPs in 3,532 affected individuals (cases) and 5,120 controls of …

Oral microbiome dysbiosis is associated with oral disease and potentially with systemic
diseases; however, the determinants of these microbial imbalances are largely unknown. In a …

Background The prevalence of class III obesity (body mass index [BMI]≥40 kg/m 2 ) has
increased dramatically in several countries and currently affects 6% of adults in the US, with …

Background Quitting tobacco or alcohol use has been reported to reduce the head and neck
cancer risk in previous studies. However, it is unclear how many years must pass following …