The tuberculosis (TB) vaccine bacille Calmette-Guérin (BCG) is a live attenuated organism,
but the mutation responsible for its attenuation has never been defined. Recent genetic …

To understand the evolution, attenuation, and variable protective efficacy of bacillus
Calmette–Guérin (BCG) vaccines, Mycobacterium bovis BCG Pasteur 1173P2 has been subjected …

Modern strains of Mycobacterium tuberculosis from the Americas are closely related to
those from Europe, supporting the assumption that human tuberculosis was introduced post-…

Rationale: In a high–tuberculosis (TB) incidence area of Cape Town, South Africa, there is a
very high rate of unexplained recurrent TB. The incidence of new bacteriologically …

DNA fingerprinting of Mycobacterium tuberculosis by IS6110 restriction fragment length
polymorphism analysis requires substantial high-quality DNA. We demonstrated that, despite …

… Citation: Zwerling A, Behr MA, Verma A, Brewer TF, Menzies D, Pai M (2011) The BCG
World Atlas: A Database of Global BCG Vaccination Policies and Practices. PLoS Med 8(3) …

Vitamin D signaling through its nuclear vitamin D receptor has emerged as a key regulator
of innate immunity in humans. Here we show that hormonal vitamin D, 1,25-dihydroxyvitamin …

… Tuberculosis has a much shorter incubation period than is widely thought, say Marcel A Behr
and colleagues, and this has implications for prioritising research and public health strategies …

While the recognition of microbial infection often occurs at the cell surface via Toll-like
receptors, the cytosol of the cell is also under surveillance for microbial products that breach the …

After nearly a century of use, BCG vaccines continue to generate controversy and confusion.
Their ability to prevent tuberculosis in studies has been inconsistent. When they have been …