Background The aim of this interim analysis of a large, international phase III study was to
assess the efficacy of an AS04 adjuvanted L1 virus-like-particle prophylactic candidate …

Drosophila melanogaster, like other invertebrates, relies solely on its innate immune response
to fight invading microbes; by definition, innate immunity lacks adaptive characteristics. …

During limb outgrowth, signaling by bone morphogenetic proteins (BMPs) must be moderated
to maintain the signaling loop between the zone of polarizing activity (ZPA) and the apical …

Importance Global use of human papillomavirus (HPV) vaccines to prevent cervical cancer
is impeded by cost. A 2-dose schedule for girls may be possible. Objective To determine …

Background Studies in Drosophila have taught us a great deal about how animals regulate
the immediate innate immune response, but we still know little about how infections cause …

Background . An increase in the incidence and severity of Clostridium difficile-associated
disease in Québec and the United States has been associated with a hypervirulent strain …

The immunogenicity of the human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine (Cervarix®,
GlaxoSmithKline Biologicals) administered according to its licensed vaccination …

Infections disturb metabolic homeostasis in many contexts, but the underlying connections
are not completely understood. To address this, we use paired genetic and computational …

Mycobacterium marinum is a pathogenic mycobacterial species that is closely related to
Mycobacterium tuberculosis and causes tuberculosis-like disease in fish and frogs. We infected …

Regulating the nuclear factor-κB (NF-κB) family of transcription factors is of critical importance
to animals, with consequences of misregulation that include cancer, chronic inflammatory …