User profiles for Laurent Legault
 | Laurent Legaultassociate professor, McGill University Verified email at muhc.mcgill.ca Cited by 3534 |
Comparison of dual-hormone artificial pancreas, single-hormone artificial pancreas, and conventional insulin pump therapy for glycaemic control in patients with type …
Background The artificial pancreas is an emerging technology for the treatment of type 1
diabetes and two configurations have been proposed: single-hormone (insulin alone) and dual-…
diabetes and two configurations have been proposed: single-hormone (insulin alone) and dual-…
Glucose-responsive insulin and glucagon delivery (dual-hormone artificial pancreas) in adults with type 1 diabetes: a randomized crossover controlled trial
Background: Most patients with type 1 diabetes do not achieve their glycemic targets. We
aimed to assess the efficacy of glucose-responsive insulin and glucagon closed-loop delivery …
aimed to assess the efficacy of glucose-responsive insulin and glucagon closed-loop delivery …
[HTML][HTML] Effectiveness and safety of long-term treatment with sulfonylureas in patients with neonatal diabetes due to KCNJ11 mutations: an international cohort study
…, R Krishnaswamy, T Lafferty, L LeGault… - The lancet Diabetes & …, 2018 - thelancet.com
Background KCNJ11 mutations cause permanent neonatal diabetes through pancreatic
ATP-sensitive potassium channel activation. 90% of patients successfully transfer from insulin to …
ATP-sensitive potassium channel activation. 90% of patients successfully transfer from insulin to …
Outpatient overnight glucose control with dual-hormone artificial pancreas, single-hormone artificial pancreas, or conventional insulin pump therapy in children and …
Background Additional benefits of the dual-hormone (insulin and glucagon) artificial
pancreas compared with the single-hormone (insulin alone) artificial pancreas have not been …
pancreas compared with the single-hormone (insulin alone) artificial pancreas have not been …
[HTML][HTML] Efficacy of single-hormone and dual-hormone artificial pancreas during continuous and interval exercise in adult patients with type 1 diabetes: randomised …
Aims/hypothesis The aim of this study was to assess whether the dual-hormone (insulin and
glucagon) artificial pancreas reduces hypoglycaemia compared with the single-hormone (…
glucagon) artificial pancreas reduces hypoglycaemia compared with the single-hormone (…
A novel dual-hormone insulin-and-pramlintide artificial pancreas for type 1 diabetes: a randomized controlled crossover trial
…, E Pytka, A El Fathi, N Strauss, L Legault - Diabetes …, 2020 - Am Diabetes Assoc
OBJECTIVE The rapid insulin-alone artificial pancreas improves glycemia in type 1 diabetes
but daytime control remains suboptimal. We propose two novel dual-hormone artificial …
but daytime control remains suboptimal. We propose two novel dual-hormone artificial …
The challenges of achieving postprandial glucose control using closed‐loop systems in patients with type 1 diabetes
For patients with type 1 diabetes, closed‐loop delivery systems ( CLS ) combining an insulin
pump, a glucose sensor and a dosing algorithm allowing a dynamic hormonal infusion have …
pump, a glucose sensor and a dosing algorithm allowing a dynamic hormonal infusion have …
Type 1 diabetes in children and adolescents
Diabetes mellitus is the most common endocrine disease and one of the most common
chronic conditions in children. Type 2 diabetes and other types of diabetes, including genetic …
chronic conditions in children. Type 2 diabetes and other types of diabetes, including genetic …
[HTML][HTML] A fully artificial pancreas versus a hybrid artificial pancreas for type 1 diabetes: a single-centre, open-label, randomised controlled, crossover, non-inferiority …
…, N Garfield, J Rutkowski, J Rene, L Legault… - The Lancet Digital …, 2021 - thelancet.com
Background For people with type 1 diabetes, there is currently no automated insulin delivery
system that does not require meal input. We aimed to assess the efficacy of a novel faster-…
system that does not require meal input. We aimed to assess the efficacy of a novel faster-…
Single-and dual-hormone artificial pancreas for overnight glucose control in type 1 diabetes
Context: The added benefit of glucagon in artificial pancreas systems for overnight glucose
control in type 1 diabetes has not been fully explored. Objective: The objective of the study …
control in type 1 diabetes has not been fully explored. Objective: The objective of the study …