User profiles for Laura E. Rosen
 | Laura E RosenVir Biotechnology Verified email at vir.bio Cited by 7392 |
[PDF][PDF] Mapping neutralizing and immunodominant sites on the SARS-CoV-2 spike receptor-binding domain by structure-guided high-resolution serology
…, M Beltramello, C Silacci-Fregni, D Pinto, LE Rosen… - Cell, 2020 - cell.com
Analysis of the specificity and kinetics of neutralizing antibodies (nAbs) elicited by SARS-CoV-2
infection is crucial for understanding immune protection and identifying targets for …
infection is crucial for understanding immune protection and identifying targets for …
Structural basis of SARS-CoV-2 Omicron immune evasion and receptor engagement
M McCallum, N Czudnochowski, LE Rosen, SK Zepeda… - Science, 2022 - science.org
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant of
concern evades antibody-mediated immunity that comes from vaccination or infection with …
concern evades antibody-mediated immunity that comes from vaccination or infection with …
Broadly neutralizing antibodies overcome SARS-CoV-2 Omicron antigenic shift
The recently emerged SARS-CoV-2 Omicron variant encodes 37 amino acid substitutions in
the spike protein, 15 of which are in the receptor-binding domain (RBD), thereby raising …
the spike protein, 15 of which are in the receptor-binding domain (RBD), thereby raising …
SARS-CoV-2 immune evasion by the B. 1.427/B. 1.429 variant of concern
…, AF Pellanda, C Garzoni, WC Van Voorhis, LE Rosen… - Science, 2021 - science.org
A novel variant of concern (VOC) named CAL.20C (B.1.427/B.1.429), which was originally
detected in California, carries spike glycoprotein mutations S13I in the signal peptide, W152C …
detected in California, carries spike glycoprotein mutations S13I in the signal peptide, W152C …
SARS-CoV-2 RBD antibodies that maximize breadth and resistance to escape
An ideal therapeutic anti-SARS-CoV-2 antibody would resist viral escape 1 , 2 – 3 , have
activity against diverse sarbecoviruses 4 , 5 , 6 – 7 , and be highly protective through viral …
activity against diverse sarbecoviruses 4 , 5 , 6 – 7 , and be highly protective through viral …
Ultrapotent human antibodies protect against SARS-CoV-2 challenge via multiple mechanisms
Efficient therapeutic options are needed to control the spread of severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) that has caused more than 922,000 fatalities as of 13 …
syndrome coronavirus 2 (SARS-CoV-2) that has caused more than 922,000 fatalities as of 13 …
[PDF][PDF] N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2
The SARS-CoV-2 spike (S) glycoprotein contains an immunodominant receptor-binding
domain (RBD) targeted by most neutralizing antibodies (Abs) in COVID-19 patient plasma. Little …
domain (RBD) targeted by most neutralizing antibodies (Abs) in COVID-19 patient plasma. Little …
Broad betacoronavirus neutralization by a stem helix–specific human antibody
The spillovers of betacoronaviruses in humans and the emergence of severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) variants highlight the need for broad coronavirus …
syndrome coronavirus 2 (SARS-CoV-2) variants highlight the need for broad coronavirus …
Molecular basis of immune evasion by the Delta and Kappa SARS-CoV-2 variants
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission leads to the
emergence of variants, including the B.1.617.2 (Delta) variant of concern that is causing a …
emergence of variants, including the B.1.617.2 (Delta) variant of concern that is causing a …
Broad sarbecovirus neutralization by a human monoclonal antibody
The recent emergence of SARS-CoV-2 variants of concern 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 – 10
and the recurrent spillovers of coronaviruses 11 , 12 into the human population highlight the …
and the recurrent spillovers of coronaviruses 11 , 12 into the human population highlight the …
