Introduction Retrospective studies have shown immune-related adverse events (irAEs) to
be associated with better prognosis. However, no prospective clinical trials have been …

Background Periostin, an extracellular matrix protein, contributes to subepithelial thickening
in asthmatic airways, and its serum levels reflect airway eosinophilic inflammation. However, …

Background: Small airways play important roles in the pathophysiology of asthma. However,
relationships between small airway involvement and health status and dyspnea have not …

BACKGROUND: Small airways appear to have an important role in asthma. Hydrofluoroalkane-134a
beclomethasone dipropionate (HFA-BDP) has ultrafine particles and accordingly …

Background Omalizumab, a humanized anti-IgE monoclonal antibody, is reportedly an
effective treatment for severe allergic asthma. However, there have been few comprehensive …

Concurrent chemoradiation therapy (CCRT) is the treatment of choice for locally advanced
non-small cell lung cancer (LA-NSCLC). Several clinical trials that combine programmed cell …

BACKGROUND: We evaluated the efficacy of high-flow nasal cannula (HFNC) therapy, a
promising respiratory support method for acute hypoxemic respiratory failure (AHRF). …

Use of plasma DNA to detect mutations has spread widely as a form of liquid biopsy. EGFR
T790M has been observed in half of lung cancer patients who have acquired resistance to …

BACKGROUND: Early enteral nutrition is recommended for mechanically ventilated patients
in several studies and guidelines. In contrast, the effects of early enteral nutrition on …

Introduction Nivolumab has demonstrated efficacy against metastatic non-small cell lung
cancer (NSCLC). However, immune-related adverse events can occur, among which …