Muscle stem cells (MuSCs) reside in a specialized niche that ensures their regenerative
capacity. Although we know that innate immune cells infiltrate the niche in response to injury, it …

Bromodomains (BRDs) are conserved protein interaction modules which recognize (read)
acetyl-lysine modifications, however their role(s) in regulating cellular states and their …

The evolution of the cancer cell into a metastatic entity is the major cause of death in patients
with cancer. It has been acknowledged that aberrant activation of a latent embryonic …

Ovarian cancer (OVCA) is the most lethal gynecological cancer, due predominantly to late
presentation, high recurrence rate and common chemoresistance development. The …

The X chromosome–encoded histone demethylase UTX (also known as KDM6A) mediates
removal of repressive trimethylation of histone H3 lysine 27 (H3K27me3) to establish …

Background Skeletal muscles express a highly specialized proteome that allows the
metabolism of energy sources to mediate myofiber contraction. This muscle-specific proteome is …

Stem cells are continuously challenged with the decision to either self-renew or adopt a new
fate. Self-renewal is regulated by a system of cellular memory, which must be bypassed for …

Pre-mRNA splicing is a complex regulatory nexus modulated by various trans-factors and
their posttranslational modifications to create a dynamic transcriptome through alternative …

Negative elongation factor (NELF) is a critical transcriptional regulator that stabilizes paused
RNA polymerase to permit rapid gene expression changes in response to environmental …

Background: Early in the COVID-19 pandemic, the South Asian community in the Greater
Toronto Area (GTA) was identified as having risk factors for exposure and specific barriers to …