Background Metagenomic next-generation sequencing (NGS) of cerebrospinal fluid (CSF)
has the potential to identify a broad range of pathogens in a single test. Methods In a 1-year, …

Appropriate use and interpretation of serological tests for assessments of severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) exposure, infection and potential immunity …

Appropriate use and interpretation of serological tests for assessments of SARS-CoV-2
exposure, infection and potential immunity require accurate assay performance data. We …

Importance Identifying infectious causes of subacute or chronic meningitis can be challenging.
Enhanced, unbiased diagnostic approaches are needed. Objective To present a case …

A 37-year-old man with a history of seminoma presented with vertigo, ataxia, and diplopia.
An autoantibody specific for kelch-like protein 11 (KLHL11) was identified with the use of …

Objective Immunodeficient patients are particularly vulnerable to neuroinvasive infections
that can be challenging to diagnose. Metagenomic next generation sequencing can identify …

Comprehensive understanding of the serological response to SARS-CoV-2 infection is important
for both pathophysiologic insight and diagnostic development. Here, we generate a pan…

Since 2012, the United States of America has experienced a biennial spike in pediatric
acute flaccid myelitis (AFM) 1 , 2 , 3 , 4 , 5 – 6 . Epidemiologic evidence suggests non-polio …

Importance Neuropsychiatric manifestations of COVID-19 have been reported in the
pediatric population. Objective To determine whether anti–SARS-CoV-2 and autoreactive …

Objective Rapid‐onset Obesity with Hypothalamic Dysfunction, Hypoventilation and Autonomic
Dysregulation (ROHHAD), is a severe pediatric disorder of uncertain etiology resulting in …