Methods The Canadian Research Initiative in Substance Misuse (CRISM), a Canadian
Institutes of Health Research (CIHR)–funded research network composed of four regional …

Importance Although prescription opioid use disorder is associated with substantial harms,
strategies to identify patients with pain among whom prescription opioids can be safely …

Importance Although severe alcohol withdrawal syndrome (SAWS) is associated with substantial
morbidity and mortality, most at-risk patients will not develop this syndrome. Predicting …

Objective: Extensive exposure to prescription-type opioids has resulted in major harm worldwide,
calling for better-adapted approaches to opioid agonist therapy. The authors aimed to …

Background and aims HIV‐infected people with substance use disorders are least likely to
benefit from advances in HIV treatment. Integration of extended‐release naltrexone (XR‐NTX) …

Background and Aims For HIV‐positive individuals who use illicit opioids, engagement in
methadone maintenance therapy (MMT) can contribute to improved HIV treatment outcomes. …

Background HIV infection in people who inject drugs (PWID) is an international public
health concern. We aimed to assess the effect of methadone maintenance therapy on HIV …

Background Rates of non-medical use of opioids, and opioid use disorders (OUD) have
been rising throughout North America. Methadone and buprenorphine/naloxone are the …

Background: Implementation of evidence-based approaches to the treatment of various
substance use disorders is needed to tackle the existing epidemic of substance use and related …

Background Although opioid-agonist therapy with methadone or buprenorphine/naloxone is
currently the mainstay of medical treatment for opioid use disorder, these medications often …