Targeted nanoparticles for quantitative imaging of sparse molecular epitopes with MRI

AM Morawski, PM Winter, KC Crowder… - … in Medicine: An …, 2004 - Wiley Online Library
Before molecular imaging with MRI can be applied clinically, certain problems, such as the
potential sparseness of molecular epitopes on targeted cell surfaces, and the relative …

Sonic activation of molecularly-targeted nanoparticles accelerates transmembrane lipid delivery to cancer cells through contact-mediated mechanisms: implications …

KC Crowder, MS Hughes, JN Marsh… - Ultrasound in medicine …, 2005 - Elsevier
Liquid perfluorocarbon nanoparticles serve as sensitive and specific targeted contrast and
drug delivery vehicles by binding to specific cell surface markers. We hypothesized that …

The impact of high-sensitivity troponin implementation on hospital operations and patient outcomes in 3 tertiary care centers

KR Crowder, TD Jones, ES Lang, DM Wang… - The American Journal of …, 2015 - Elsevier
Objective High-sensitivity troponin T (hs-TnT) assays detect myocardial injury sooner, possibly
improving throughput times for emergency department (ED) assessment of suspected …

Buprenorphine–naloxone practice and attitudes in 22 Canadian emergency physician groups: a cross-sectional survey

…, M Klaiman, J Yan, JJ Koh, K Crowder… - … Open Access Journal, 2021 - cmajopen.ca
Background: Buprenorphine–naloxone (BUP) initiation in emergency departments improves
follow-up and survival among patients with opioid use disorder. We aimed to assess self-…

The multicenter impacts of an emergency physician lead on departmental flow and provider experiences

K Crowder, E Domm, R Lipp, O Robinson… - Canadian Journal of …, 2023 - Springer
Introduction Emergency department (ED) flow impacts patient safety, quality of care and ED
provider satisfaction. Throughput interventions have been shown to improve flow, yet few …

[HTML][HTML] Factors associated with frequent buprenorphine/naloxone initiation in a national survey of Canadian emergency physicians

…, G Andolfatto, M Klaiman, J Yan, JJ Koh, K Crowder… - Plos one, 2024 - journals.plos.org
Objective To identify individual and site-related factors associated with frequent emergency
department (ED) buprenorphine/naloxone (BUP) initiation. BUP initiation, an effective opioid …

Augmented and selective delivery of liquid perfluorocarbon nanoparticles to melanoma cells with noncavitational ultrasound

KC Crowder, MS Hughes, JN Marsh… - IEEE Symposium on …, 2003 - ieeexplore.ieee.org
Our laboratory previously has demonstrated the ability of liquid perfluoro-carbon (PFC)
nanoparticles to serve as site-targeted contrast and therapeutic agents by specifically binding …

[HTML][HTML] Alternatives to the transfer of long-term care patients to emergency departments: a new kind of house call?

K Crowder, E Lang - Canadian Journal of Emergency Medicine, 2023 - Springer
Long-term care (LTC) residents have unique care needs such that ageing, medical complexity,
frailty, polypharmacy and increasing care requirements have all been associated with a …

In vitro acoustic molecular imaging of tissue factor expressed by smooth muscle cells with stable liquid perfluorocarbon nanoparticle contrast agents

JN Marsh, KC Crowder, MS Hughes… - IEEE Ultrasonics …, 2004 - ieeexplore.ieee.org
Liquid perfluorocarbon nanoparticle contrast agents can be used to target specific tissue types
through incorporation of appropriate ligands into the nanoparticles' outer lipid monolayer. …

Unique perfluorocarbon nanobeacons improve stem/progenitor cell tracking with MRI

K Crowder, J Brant, J Chen, A Neubauer, T Meyerrose… - 2006 - Wiley Online Library
Conventional 1 H Magnetic Resonance Imaging (MRI) has been employed to define the
migratory behavior of stem/progenitor cells noninvasively in vivo. In contrast, we propose …