Background In acquired thrombotic thrombocytopenic purpura (TTP), an immune-mediated
deficiency of the von Willebrand factor–cleaving protease ADAMTS13 allows unrestrained …

Importance Blood transfusion is one of the most frequently used therapies worldwide and is
associated with benefits, risks, and costs. Objective To develop a set of evidence-based …

Approximately five decades ago, alloimmunization to human leukocyte antigens (HLA) and
platelet refractoriness were recognized as potentially serious complications of platelet …

Novel oral anticoagulants (NOACs)(rivaroxaban, dabigatran, apixaban) have been approved
by international regulatory agencies to treat atrial fibrillation and venous thromboembolism …

Importance Excessive bleeding is a common complication of cardiac surgery. An important
cause of bleeding is acquired hypofibrinogenemia (fibrinogen level <1.5-2.0 g/L), for which …

Immune-mediated thrombotic thrombocytopenic purpura (iTTP) is a potentially fatal thrombotic
microangiopathy caused by autoantibody-mediated severe deficiency of ADAMTS13. …

Importance Red blood cell transfusion is a common medical intervention with benefits and
harms. Objective To provide recommendations for use of red blood cell transfusion in adults …

Patients with hypoproliferative thrombocytopenia are at an increased risk for hemorrhage and
alloimmunization to platelets. Updated guidance for optimizing platelet transfusion therapy …

The efficacy and safety of caplacizumab in individuals with acquired thrombotic
thrombocytopenic purpura (aTTP) have been established in the phase 2 TITAN and phase 3 …

Purpose Iron restricted anemia is prevalent in surgical patients and is associated with an
increased risk of allogeneic red blood cell (RBC) transfusion and adverse events. Treatment of …