Background Few effective treatments exist for patients with advanced urothelial carcinoma
that has progressed after platinum-based chemotherapy. We assessed the activity and safety …

The objective of this study was to report on the prevalence and correlates of anxiety and
mood problems among 9- to 14- year-old children with Asperger syndrome (AS) and high-…

Background. A number of US observational studies reported an increased mortality risk with
higher intact parathyroid hormone (iPTH), calcium and/or phosphate. The existence of such …

Human cancer genomes harbour a variety of alterations leading to the deregulation of key
pathways in tumour cells. The genomic characterization of tumours has uncovered numerous …

The three-dimensional structure of a TATA-box binding polypeptide complexed with the
TATA element of the adenovirus major late promoter has been determined by X-ray …

The X-ray structure of the ternary complex of a calcineurin A fragment, calcineurin B,
FKBP12, and the immunosuppreseant drug FK506 (also known as tacrolimus) has been …

Pancreatic cancer is the most lethal common solid malignancy. Systemic therapies are often
ineffective, and predictive biomarkers to guide treatment are urgently needed. We …

Background: Hepatitis C virus (HCV) represents a major health concern as it is responsible
for a significant number of hepatitis cases worldwide. Much research has focused on the …

Purpose Metastatic esophagogastric cancer treatments after failure of second-line chemotherapy
are limited. Nivolumab demonstrated superior overall survival (OS) versus placebo in …

Background: Cell-free DNA circulating in blood is a candidate biomarker for malignant
tumors. Unlike uniformly truncated DNA released from apoptotic nondiseased cells, DNA …