Background Mesenchymal stromal cells (MSCs, “adult stem cells”) have been widely used
experimentally in a variety of clinical contexts. There is interest in using these cells in critical …

Background Vasopressin is commonly used as an adjunct to catecholamines to support blood
pressure in refractory septic shock, but its effect on mortality is unknown. We hypothesized …

Background A strategy of mechanical ventilation that limits airway pressure and tidal volume
while permitting hypercapnia has been recommended for patients with the acute respiratory …

Background Previous trials suggesting that high-frequency oscillatory ventilation (HFOV)
reduced mortality among adults with the acute respiratory distress syndrome (ARDS) were …

Background— Eisenmenger syndrome is characterized by the development of pulmonary
arterial hypertension with consequent intracardiac right-to-left shunt and hypoxemia in …

The demands on a pulmonary arterial hypertension (PAH) treatment algorithm are multiple
and in some ways conflicting. The treatment algorithm usually includes different types of …

Context Protocolized sedation and daily sedation interruption are 2 strategies to minimize
sedation and reduce the duration of mechanical ventilation and intensive care unit (ICU) stay. …

Observational studies of high-frequency oscillatory ventilation in adults with the acute
respiratory distress syndrome have demonstrated improvements in oxygenation. We designed a …

Objective To review the literature on the use of inhaled nitric oxide to treat acute lung injury/acute
respiratory distress syndrome (ALI/ARDS) and to summarise the effects of nitric oxide, …

Objective: Delirium is common during critical illness and associated with adverse outcomes.
We compared characteristics and outcomes of delirious and nondelirious patients enrolled …