Although hyperthermia offers clinical appeal to sensitize cells to chemotherapy, this approach
has been limited in terms of long-term outcome as well as economic and technical burden. …

Cancer associated fibroblasts (CAFs) play a critical role for growth, invasion, and metastasis
of cancer. Therefore, targeting CAFs with small molecule inhibitors may be an attractive anti-…

The influence of 3D microenvironments on apoptosis susceptibility remains poorly
understood. Here, we studied the susceptibility of cancer cell spheroids, grown to the size of …

Current understanding of the p53 response is based mainly upon in vitro studies of homogeneous
cell populations. However, there is little information on whether the same principles …

Background: Early resuscitation with blood components or products is emerging as best
practice in selected patients with trauma and medical patients; as a result, out-of-hospital …

High frequency recombination-line observations made with the Effelsberg 100-m telescope
are used to determine the variation of the electron temperature of galactic H II regions with …

LAY SUMMARY As a result of the unpredictable nature of warfare, military medics deployed
on missions may be required to manage seriously ill or injured patients for longer than …

In the past two decades, the Argo Program has collected, processed, and distributed over
two million vertical profiles of temperature and salinity from the upper two kilometers of the …

Decades of theory and empirical studies have demonstrated links between biodiversity and
ecosystem functioning, yet the putative processes that underlie these patterns remain elusive…

Extracellular matrix-like molecule reelin and cell surface adhesion receptors such as α3β1
integrin can regulate neuronal migration and position in the developing cerebral cortex. Here …