Background Recent guidelines recommend consideration of germline testing for all newly
diagnosed pancreatic ductal adenocarcinoma (PDAC). The primary aim of this study was to …

New streamlined models for genetic counseling and genetic testing have recently been
developed in response to increasing demand for cancer genetic services. To improve access …

Background The SDHD gene encodes a subunit of the mitochondrial tricarboxylic acid cycle
enzyme and tumor suppressor, succinate dehydrogenase. Mutations in this gene show a …

Background Multi‐gene panel testing is replacing single‐gene testing for patients with
suspected hereditary cancer syndromes. The detection of a hereditary cancer syndrome allows …

Lynch syndrome is defined by the presence of germline mutations in mismatch repair (MMR)
genes. Several models have been recently devised that predict mutation carrier status (…

Cascade genetic testing for hereditary cancer is highly accurate and cost-effective for
identifying individuals at high risk for cancer; however, not all eligible people utilize this service. …

Increasing demand for genetic services has led to the development of streamlined genetic
counseling (GC) models. We piloted large‐scale group pre‐test GC with up to 50 patients per …

Background: Genetic testing in families with hereditary cancer enables identification of
people most likely to benefit from intensive screening and preventive measures; however, the …

Introduction Genetic testing for hereditary cancer syndromes (HCSs) can improve health
outcomes through cancer risk mitigation strategies. Effective communication between tested …

For 21 putative BRCA1 and BRCA2 splice site variants, the concordance between mRNA
analysis and predictions by in silico programs was evaluated. Aberrant splicing was confirmed …