Background On the basis of encouraging preliminary results, we conducted a randomized,
controlled trial to determine whether minocycline reduces the risk of conversion from a first …

Background: Depression is a common comorbidity in multiple sclerosis (MS), but little is
known about its long-term prognosis. Depression in the general population is usually episodic …

Background: Identification of therapies to prevent severe COVID-19 remains a priority. We
sought to determine whether hydroxychloroquine treatment for outpatients with SARS-CoV-2 …

Background: Recent evidence suggests a role for the gut–brain axis in the pathophysiology
of multiple sclerosis (MS). Materials and methods: We studied biomarkers of intestinal …

Background Epidemiological, pathological and radiological studies suggest that inflammatory
demyelination in MS is an age-dependent process, and that the formation of focal …

Disease modifying therapies (DMTs) reduce the frequency of relapses and accumulation of
disability in multiple sclerosis (MS). Long-term persistence with treatment is important to …

Background Risk factors for psychiatric comorbidity in multiple sclerosis (MS) are poorly
understood. Objective We evaluated the association between physical comorbidity and incident …

Background Primary progressive multiple sclerosis (PPMS) is the least common MS
disease course and carries the worst prognosis. In relapsing–remitting multiple sclerosis (RRMS) …

Background Research on the health benefits of cannabis has been limited because use
remains restricted or illegal in most countries. Medical cannabis has been legal in Canada since …

Methods The nine hole peg test (9HPT) is an emerging outcome measure in clinical trials in
multiple sclerosis (MS). In this study we investigated how performance on the 9HPT at …