Receiver operating characteristic (ROC) curves are used to describe and compare the
performance of diagnostic technology and diagnostic algorithms. This paper refines the statistical …

A representation and interpretation of the area under a receiver operating characteristic (ROC)
curve obtained by the "rating" method, or by mathematical predictions based on patient …

The method of generalized estimating equations (GEE) is often used to analyze longitudinal
and other correlated response data, particularly if responses are binary. However, few …

ContextThe appropriate therapy for men with clinically localized prostate cancer is uncertain.
A recent study suggested an increasing prostate cancer mortality rate for men who are alive …

PHYSICIANS frequently must provide patients with estimates of the risk of a particular medical
procedure or of the probability of a specific health outcome. To do so, they may use data …

ContextRising costs of medications and inequities in access have sparked calls for drug policy
reform in the United States and Canada. Control of drug expenditures by prescription cost-…

Context.—The appropriate therapy for men with localized prostate cancer is uncertain. Until
results of clinical trials are available, men and their physicians need guidance.Objective.—…

… James A Hanley, professor of biostatistics1… Yee A, Majumdar SR, Simpson SH,
McAlister FA, Tsuyuki RT, Johnson JA. Statin use in type 2 diabetes mellitus is associated …

Random measurement error is a pervasive problem in medical research, which can introduce
bias to an estimate of the association between a risk factor and a disease or make a true …

… Unfortunately, as was pointed out by Hanley and Begg,37 this claim is not valid; the algebra
used … McNeil, BJ and Hanley, JA, Statistical approaches to the analysis of receiver operating …