Importance The association between changes in atherosclerotic plaque induced by lipid-lowering
therapies (LLTs) and reduction in major adverse cardiovascular events (MACEs) …

It is well accepted that both apolipoprotein AI (apoA-I) and ABCA1 play crucial roles in HDL
biogenesis and in the human atheroprotective system. However, the nature and specifics of …

Introduction Statins are the cornerstone for atherosclerotic cardiovascular disease risk reduction
with recognized efficacy in primary and secondary prevention. Despite this, they remain …

The specifics of nascent HDL remodeling within the plasma compartment remain poorly
understood. We developed an in vitro assay to monitor the lipid transfer between model nascent …

Background— Low levels of high-density lipoprotein (HDL) cholesterol constitutes a major
risk factor for atherosclerosis. Recent studies from our group reported a genetic association …

Background— A low level of plasma high-density lipoprotein cholesterol (HDL-C) is a risk
factor for cardiovascular disease. HDL particles are modulated by a variety of lipases, …

The molecular mechanisms underlying the apoA-I/ABCA1 endocytic trafficking pathway in
relation to high density lipoprotein (HDL) formation remain poorly understood. We have …

Recent studies have identified an ABCA1-dependent, phosphatidylcholine-rich microdomain,
called the "high-capacity binding site" (HCBS), that binds apoA-I and plays a pivotal role in …

The adenosine triphosphate-binding cassette A1 (ABCA1) gene codes for a cellular
phospholipid and cholesterol transporter that mediates the initial and essential step in high-density …

Background Homozygous familial hypercholesterolemia (HoFH) is a rare genetic disease
characterized by very high levels of low-density lipoprotein cholesterol (LDL-C). Untreated …