Purpose Although body composition has emerged as an important predictor of drug efficacy
and toxicity, explanations for this association are unclear. Our goal was to investigate …

BACKGROUND: Surgery followed by adjuvant chemotherapy has been standard treatment
for stage III colon cancer since 1990. However, to date, clinical trials have not been …

Objective: To document the rates of intentional self-harm and mental disorders among
youths aged 13 to 17 years visiting Ontario emergency departments (EDs) from 2003-2017. …

BACKGROUND: Lack of health insurance is a key barrier to accessing care for chronic
conditions and cancer screening. The influence of insurance type (private, public, none) on …

Background Studies have reported increasing incidence rates of paediatric diabetes, especially
among those aged 0–5 years. Epidemiological evidence linking ambient air pollution to …

Background Adjuvant trastuzumab for early-stage (I-III) HER2-positive breast cancer (BC)
has led to statistically significant improvement in cancer outcomes but carries a risk of …

Background Cardiovascular malformations account for nearly one-third of all congenital
anomalies, making these the most common type of birth defects. Little is known regarding the …

Objective To examine the impact of neighbourhood marginalization on avoidable mortality (AM)
from preventable and treatable causes of death. Methods All premature deaths between …

Background Ambient air pollution has been associated with childhood cancer. However,
little is known about the possible impact of ambient ultrafine particles (<0.1 μm) (UFPs) on …

BACKGROUND: Self-harm is increasing among adolescents, and because of changing
behaviours, current data are needed on the consequences of self-harm. We sought to …