Background Homozygous familial hypercholesterolaemia (HoFH) is a rare inherited disorder
resulting in extremely elevated low-density lipoprotein cholesterol levels and premature …

Inflammation is a major factor underlying acute coronary syndromes (ACS). HDL particles
may be remodeled, becoming functionally defective, under the inflammatory conditions seen …

Background The European Atherosclerosis Society Familial Hypercholesterolaemia Studies
Collaboration (FHSC) global registry provides a platform for the global surveillance of …

Background The current interpretation of the increased risk of ischemic heart disease (IHD)
associated with reduced low density lipoprotein (LDL) particle size is based entirely on data …

Familial hypercholesterolemia (FH) is the most common monogenic disorder causing premature
atherosclerotic cardiovascular disease. It affects 1 in 250 individuals worldwide, and of …

Familial hypercholesterolemia (FH) is the most common genetic disorder causing premature
cardiovascular disease and death. Heterozygous FH conservatively affects approximately 1:…

Background Autosomal dominant hypercholesterolemia (ADH) is caused by mutations in the
low density lipoprotein receptor (LDLR), its ligand apoB (APOB) or proprotein convertase …

Familial hypercholesterolemia (FH) is an autosomal codominant lipoprotein disorder
characterized by elevated low-density lipoprotein cholesterol (LDL-C) and high risk of premature …

It is well accepted that both apolipoprotein AI (apoA-I) and ABCA1 play crucial roles in HDL
biogenesis and in the human atheroprotective system. However, the nature and specifics of …

BACKGROUND Familial hypercholesterolemia (FH) is the most frequent genetic disorder
seen clinically and is characterized by increased LDL cholesterol (LDL-C) (>95th percentile), …