During latest Quaternary glaciation, the Black Sea became a giant freshwater lake. The
surface of this lake drew down to levels more than 100 m below its outlet. When the …

Introduction Comparative data on the burden of atopic dermatitis (AD) in adults relative to
the general population are limited. We performed a large-scale evaluation of the burden of …

Reactive oxygen species (ROS) have been suggested to play an important role in
physiopathology of schizophrenia. The major intracellular antioxidant enzymes, copper–zinc …

Objectives This study evaluated the prevalence rate of vaso-occlusive crisis (VOC) episodes,
rates of uncomplicated and complicated VOC episodes, and the primary reasons for …

Background Patient frailty amongst patients with nonvalvular atrial fibrillation (NVAF) is
associated with adverse health outcomes and increased risk of mortality. Additional evidence is …

Background Patients with cancer are more likely to develop nonvalvular atrial fibrillation (NVAF).
Currently there are no definitive clinical trials or treatment guidelines for NVAF patients …

Background This study aimed to evaluate sickle-cell disease (SCD) treatment patterns and
economic burden among patients prescribed hydroxyurea (HU) in the US, through claims …

OBJECTIVES Older adult patients are underrepresented in clinical trials comparing non–vitamin
K antagonist oral anticoagulants (NOACs) and warfarin. This subgroup analysis of the …

Importance Many patients with nonvalvular atrial fibrillation (NVAF) are at a high risk of
gastrointestinal (GI) bleeding due to conditions including older age; stage III to V chronic kidney …

Objectives The study aimed to assess the burden of RA among the US Medicare population
(aged ≥65 years) by comparing co-morbidities, health-care resource utilization (HCRU) …