[HTML][HTML] Improvements to the ARTIC multiplex PCR method for SARS-CoV-2 genome sequencing using nanopore

…, A Wickenhagen, G Hall, JH Choi, H Lapointe… - BioRxiv, 2020 - ncbi.nlm.nih.gov
Genome sequencing has been widely deployed to study the evolution of SARS-CoV-2 with
more than 90,000 genome sequences uploaded to the GISAID database. We published a …

Reduced magnitude and durability of humoral immune responses to COVID-19 mRNA vaccines among older adults

MA Brockman, F Mwimanzi, HR Lapointe… - The Journal of …, 2022 - academic.oup.com
Background The magnitude and durability of immune responses to coronavirus disease
2019 (COVID-19) mRNA vaccines remain incompletely characterized in the elderly. Methods …

Humoral immune responses to COVID-19 vaccination in people living with HIV receiving suppressive antiretroviral therapy

ZL Brumme, F Mwimanzi, HR Lapointe, PK Cheung… - npj Vaccines, 2022 - nature.com
Humoral responses to COVID-19 vaccines in people living with HIV (PLWH) remain
incompletely characterized. We measured circulating antibodies against the SARS-CoV-2 spike …

Older adults mount less durable humoral responses to two doses of COVID-19 mRNA vaccine but strong initial responses to a third dose

F Mwimanzi, HR Lapointe, PK Cheung… - The Journal of …, 2022 - academic.oup.com
Hope R Lapointe , Hope R Lapointe … We thank the phlebotomists and laboratory staff at St
Paul's Hospital, the BC Centre for Excellence in HIV/AIDS, the Hope to Health Research and …

[HTML][HTML] People with HIV receiving suppressive antiretroviral therapy show typical antibody durability after dual COVID-19 vaccination, and strong third dose …

HR Lapointe, F Mwimanzi, PK Cheung, Y Sang… - medRxiv, 2022 - ncbi.nlm.nih.gov
Background: Longer-term humoral responses to two-dose COVID-19 vaccines remain
incompletely characterized in people living with HIV (PLWH), as do initial responses to a third …

SARS CoV-2 mRNA vaccination exposes latent HIV to Nef-specific CD8+ T-cells

…, D Betel, F Dündar, MC Duncan, HR Lapointe… - Nature …, 2022 - nature.com
Efforts to cure HIV have focused on reactivating latent proviruses to enable elimination by
CD8 + cytotoxic T-cells. Clinical studies of latency reversing agents (LRA) in antiretroviral …

COVID-19 vaccine immunogenicity in people with HIV

…, DHS Tan, M Harris, M Hull, ZL Brumme, HR Lapointe… - Aids, 2023 - journals.lww.com
In a multi-center longitudinal observational cohort of people with HIV in Canada, COVID-19
vaccination humoral immunogenicity was assessed in 294 individuals with and 267 without …

People with human immunodeficiency virus receiving suppressive antiretroviral therapy show typical antibody durability after dual coronavirus disease 2019 …

HR Lapointe, F Mwimanzi, PK Cheung… - The Journal of …, 2023 - academic.oup.com
Background Longer-term humoral responses to 2-dose coronavirus disease 2019 (COVID-19)
vaccines remain incompletely characterized in people living with human …

Antibody response durability following three-dose coronavirus disease 2019 vaccination in people with HIV receiving suppressive antiretroviral therapy

HR Lapointe, F Mwimanzi, PK Cheung, Y Sang… - Aids, 2023 - journals.lww.com
Background: Limited data exist regarding longer term antibody responses following three-dose
coronavirus disease 2019 (COVID-19) vaccination, and the impact of a first SARS-CoV-2 …

[HTML][HTML] Weak humoral immune reactivity among residents of long-term care facilities following one dose of the BNT162b2 mRNA COVID-19 vaccine

…, Y Sang, K Ng, O Agafitei, S Ennis, H Lapointe… - medRxiv, 2021 - ncbi.nlm.nih.gov
Background. Several Canadian provinces are extending the interval between COVID-19
vaccine doses to increase population vaccine coverage more rapidly. However, …