User profiles for Hannah Kaiser

Hannah Kaiser

Verified email at regionh.dk
Cited by 167

SARS-CoV-2 RBD antibodies that maximize breadth and resistance to escape

…, LE Rosen, J Zhou, M Montiel-Ruiz, H Kaiser… - Nature, 2021 - nature.com
An ideal therapeutic anti-SARS-CoV-2 antibody would resist viral escape 1 , 2 – 3 , have
activity against diverse sarbecoviruses 4 , 5 , 6 – 7 , and be highly protective through viral …

Broadly neutralizing antibodies overcome SARS-CoV-2 Omicron antigenic shift

…, A De Marco, J di Iulio, F Zatta, H Kaiser… - Nature, 2022 - nature.com
The recently emerged SARS-CoV-2 Omicron variant encodes 37 amino acid substitutions in
the spike protein, 15 of which are in the receptor-binding domain (RBD), thereby raising …

Ultrapotent human antibodies protect against SARS-CoV-2 challenge via multiple mechanisms

…, JA Wojcechowskyj, JB Case, RE Chen, H Kaiser… - Science, 2020 - science.org
Efficient therapeutic options are needed to control the spread of severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) that has caused more than 922,000 fatalities as of 13 …

Broad betacoronavirus neutralization by a stem helix–specific human antibody

…, B Guarino, LE Rosen, J di Iulio, J Jerak, H Kaiser… - Science, 2021 - science.org
The spillovers of betacoronaviruses in humans and the emergence of severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) variants highlight the need for broad coronavirus …

Lectins enhance SARS-CoV-2 infection and influence neutralizing antibodies

…, S Bianchi, AC Walls, JE Bowen, J Zhou, H Kaiser… - Nature, 2021 - nature.com
SARS-CoV-2 infection—which involves both cell attachment and membrane fusion—relies
on the angiotensin-converting enzyme 2 (ACE2) receptor, which is paradoxically found at low …

Imprinted antibody responses against SARS-CoV-2 Omicron sublineages

…, G Schnell, A Rajesh, J Zhou, N Farhat, H Kaiser… - Science, 2022 - science.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron sublineages carry
distinct spike mutations resulting in escape from antibodies induced by previous infection or …

Broad sarbecovirus neutralization by a human monoclonal antibody

…, FA Lempp, LE Rosen, E Dellota Jr, H Kaiser… - Nature, 2021 - nature.com
The recent emergence of SARS-CoV-2 variants of concern 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 – 10
and the recurrent spillovers of coronaviruses 11 , 12 into the human population highlight the …

The dual function monoclonal antibodies VIR-7831 and VIR-7832 demonstrate potent in vitro and in vivo activity against SARS-CoV-2

…, JA Wojcechowskyj, J Noack, J Zhou, H Kaiser… - biorxiv, 2021 - biorxiv.org
VIR-7831 and VIR-7832 are dual action monoclonal antibodies (mAbs) targeting the spike
glycoprotein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). VIR-7831 …

Evaluation of cell-based and surrogate SARS-CoV-2 neutralization assays

…, MD Miner, YJ Hou, LV Tse, H Kaiser… - Journal of Clinical …, 2021 - Am Soc Microbiol
Determinants of protective immunity against severe acute respiratory syndrome coronavirus
2 (SARS-CoV-2) infection require the development of well-standardized, reproducible …

Biomarkers of subclinical atherosclerosis in patients with psoriasis

H Kaiser, X Wang, A Kvist-Hansen, M Krakauer… - Scientific reports, 2021 - nature.com
Psoriasis is linked with increased risk of cardiovascular disease (CVD) that is underestimated
by traditional risk stratification. We conducted a large-scale plasma proteomic analysis by …