Urinary tract infections (UTIs) are a problem worldwide, affecting almost half a billion people
each year. Increasing antibiotic resistance and limited therapeutic options have led to the …

Whole genome sequencing (WGS) of Salmonella supports both molecular typing and
detection of antimicrobial resistance (AMR). Here, we evaluated the correlation between …

The lipid-rich cell wall is a defining feature of Mycobacterium species. Individual cell wall
components affect diverse mycobacterial phenotypes including colony morphology, biofilm …

The TolC protein of Escherichia coli is implicated in a variety of diverse cellular functions,
including antibiotic efflux and α-hemolysin secretion. An incidental role of TolC is to facilitate …

Background Lyme disease is an emerging vector-borne zoonotic disease of increasing
public health importance in Canada. As part of its mandate, the Canadian Lyme Disease …

Background: Previously we studied the antibiotic susceptibility of invasive Haemophilus
influenzae collected in Canada from 1990 to 2006 and characterized isolates by serotype, MLST …

Background Patient-level surveillance (indication, appropriate choice, dosing, route, duration)
of antimicrobial use in Canadian hospitals is needed to reduce antimicrobial overuse and …

Extended-spectrum β-lactamases (ESBLs) confer resistance to extended-spectrum
cephalosporins, a major class of clinical antimicrobial drugs. We used genomic analysis to …

This study describes the isolation and characterization of a unique class of TolC mutants that,
under steady-state growth conditions, secreted normal levels of largely inactive alpha-…

We investigated whether the increased prevalence of gentamicin resistance in Salmonella
from human infections was related to a similar increased prevalence in isolates from broiler …