Background On the basis of encouraging preliminary results, we conducted a randomized,
controlled trial to determine whether minocycline reduces the risk of conversion from a first …

Galectin-1 (Gal-1), the prototype of a family of β-galactoside-binding proteins, has been
shown to attenuate experimental acute and chronic inflammation. In view of the fact that …

Background: Identification of therapies to prevent severe COVID-19 remains a priority. We
sought to determine whether hydroxychloroquine treatment for outpatients with SARS-CoV-2 …

Objective Primary progressive multiple sclerosis (PPMS) does not respond well to
immunomodulatory or immunosuppressive treatment. Chronic activation of microglia has been …

Objective To assess whether treatment with the generic drug domperidone can reduce the
progression of disability in secondary progressive multiple sclerosis (SPMS), we conducted a …

Defective leukocyte-endothelial interactions are observed in experimental diabetes mellitus.
Endogenous substances, including nitric oxide (NO), have anti-inflammatory effects within …

Background: In the trial of Minocycline in Clinically Isolated Syndrome (MinoCIS), minocycline
significantly reduced the risk of conversion to clinically definite multiple sclerosis (CDMS). …

Background : Identification of therapies to promote repair in multiple sclerosis is challenged
by the lack of an accepted trial model and associated outcome measures. The goal of this …

Background Increasing evidence suggests that various inflammatory, immunological and
metabolic pathways are altered in the clinically isolated syndrome (CIS) of multiple sclerosis (…

Defeitos na interação leucócito-endotélio são observados no diabetes mellitus.
Substâncias endógenas, incluindo o óxido nítricos exercem efeito anti inflamatório sobre a …