Objective To investigate the credibility of authors’ claims of subgroup effects using a representative
sample of recently published randomised controlled trials. Design Systematic review. …

Objective To investigate the risk of pancreatitis associated with the use of incretin-based
treatments in patients with type 2 diabetes mellitus. Design Systematic review and meta-analysis…

Objectives To examine the association between dipeptidyl peptidase-4 (DPP-4) inhibitors
and the risk of heart failure or hospital admission for heart failure in patients with type 2 …

Background Stroke is a leading cause of death and disability, especially in low-income and
middle-income countries. We sought to quantify the importance of potentially modifiable risk …

Background There is substantial variability in the perioperative administration of aspirin in
patients undergoing noncardiac surgery, both among patients who are already on an aspirin …

Importance Little is known about the relationship between perioperative high-sensitivity
troponin T (hsTnT) measurements and 30-day mortality and myocardial injury after noncardiac …

Background Marked activation of the sympathetic nervous system occurs during and after
noncardiac surgery. Low-dose clonidine, which blunts central sympathetic outflow, may …

Background Myocardial injury after non-cardiac surgery (MINS) increases the risk of
cardiovascular events and deaths, which anticoagulation therapy could prevent. Dabigatran …

BACKGROUND: Among adults undergoing contemporary noncardiac surgery, little is
known about the frequency and timing of death and the associations between perioperative …

Background In non-surgical settings, covert stroke is more common than overt stroke and is
associated with cognitive decline. Although overt stroke occurs in less than 1% of adults after …