[HTML][HTML] Apabetalone (RVX-208) reduces vascular inflammation in vitro and in CVD patients by a BET-dependent epigenetic mechanism
…, BD Rakai, SC Stotz, CD Sarsons, D Gilham, E Daze… - Clinical …, 2019 - Springer
Background Apabetalone (RVX-208) is a bromodomain and extraterminal protein inhibitor (BETi)
that in phase II trials reduced the relative risk (RR) of major adverse cardiac events (…
that in phase II trials reduced the relative risk (RR) of major adverse cardiac events (…
[HTML][HTML] The unrecognized importance of carbon stocks and fluxes from swamps in Canada and the USA
SJ Davidson, E Dazé, E Byun, D Hiler… - Environmental …, 2022 - iopscience.iop.org
Swamps are a highly significant wetland type in North America both in terms of areal extent
and their role in terrestrial carbon cycling. These wetlands, characterized by woody …
and their role in terrestrial carbon cycling. These wetlands, characterized by woody …
[HTML][HTML] Epigenetic modulation by apabetalone counters cytokine-driven acute phase response in vitro, in mice and in patients with cardiovascular disease
S Wasiak, D Gilham, E Daze, LM Tsujikawa… - Cardiovascular …, 2020 - hindawi.com
Chronic systemic inflammation contributes to cardiovascular disease (CVD) and correlates
with the abundance of acute phase response (APR) proteins in the liver and plasma. …
with the abundance of acute phase response (APR) proteins in the liver and plasma. …
[HTML][HTML] Prolactin-inducible EDD E3 ubiquitin ligase promotes TORC1 signalling, anti-apoptotic protein expression, and drug resistance in breast cancer cells
TM MacDonald, LN Thomas, E Daze… - American Journal of …, 2019 - ncbi.nlm.nih.gov
Previously, we identified a prolactin (PRL)-inducible gene encoding EDD E3 ubiquitin
ligase in human breast cancer (BCa) cells. We reported that EDD binds the mTOR (TORC1)-…
ligase in human breast cancer (BCa) cells. We reported that EDD binds the mTOR (TORC1)-…
Top 10 research priorities for early-stage colorectal cancer: a Canadian patient-oriented priority-setting partnership
…, G Laxdal, L Dundas, D Huband, E Daze… - … Open Access Journal, 2022 - cmajopen.ca
Background: Colorectal cancer, one of the most commonly diagnosed cancers, is now being
detected earlier and treatments are improving, which means that patients are living longer. …
detected earlier and treatments are improving, which means that patients are living longer. …
Long-Term Carbon Accumulation in Temperate Swamp Soils: a Case Study from Greenock Swamp, Ontario, Canada
E Dazé, E Byun, SA Finkelstein - Wetlands, 2022 - Springer
Wetlands that develop peat are a globally significant pool of soil carbon. While some wetland
types such as bogs and fens are well characterized by the consistent development of …
types such as bogs and fens are well characterized by the consistent development of …
Epigenetic BET reader inhibitor apabetalone (RVX-208) counters proinflammatory aortic gene expression in a diet induced obesity mouse model and in human …
S Wasiak, LM Tsujikawa, E Daze, D Gilham, SC Stotz… - Atherosclerosis, 2023 - Elsevier
Background and aims Obese patients are at risk for type 2 diabetes mellitus (T2DM) and
cardiovascular disease (CVD). A lipid-rich diet promotes arterial changes by inducing …
cardiovascular disease (CVD). A lipid-rich diet promotes arterial changes by inducing …
[HTML][HTML] The BET inhibitor apabetalone decreases neuroendothelial proinflammatory activation in vitro and in a mouse model of systemic inflammation
S Wasiak, L Fu, E Daze, D Gilham… - Translational …, 2023 - degruyter.com
Brain vascular inflammation is characterized by endothelial activation and immune cell
recruitment to the blood vessel wall, potentially causing a breach in the blood – brain barrier, …
recruitment to the blood vessel wall, potentially causing a breach in the blood – brain barrier, …
[PDF][PDF] Hepatic Expression of C-Reactive Protein is Epigenetically Regulated by BET Proteins and Inhibited by Apabetalone (RVX-208) in vitro and in CVD Patients
S Wasiak, D Gilham, E Daze, C Halliday… - … and Vascular Biology, 2019 - resverlogix.com
Chronic inflammation contributes to cardiovascular disease (CVD) and is characterized by
elevated plasma levels of IL-6, IL-1β and C-reactive protein (CRP). CRP serves as a CVD …
elevated plasma levels of IL-6, IL-1β and C-reactive protein (CRP). CRP serves as a CVD …
[PDF][PDF] Apabetalone, a BET Bromodomain Inhibitor, Suppresses Inflammatory Mediators in Microglia and Vascular Endothelial Cells that Contribute to …
E Kulikowski, E Daze, S Wasiak, D Gilham… - 2018 - resverlogix.com
Results Apabetalone is an orally available small molecule in phase 3 trials for cardiovascular
disease (CVD). As an inhibitor of bromodomain and extraterminal domain (BET) proteins, …
disease (CVD). As an inhibitor of bromodomain and extraterminal domain (BET) proteins, …