[HTML][HTML] Apabetalone (RVX-208) reduces vascular inflammation in vitro and in CVD patients by a BET-dependent epigenetic mechanism

…, BD Rakai, SC Stotz, CD Sarsons, D Gilham, E Daze… - Clinical …, 2019 - Springer
Background Apabetalone (RVX-208) is a bromodomain and extraterminal protein inhibitor (BETi)
that in phase II trials reduced the relative risk (RR) of major adverse cardiac events (…

[HTML][HTML] The unrecognized importance of carbon stocks and fluxes from swamps in Canada and the USA

SJ Davidson, E Dazé, E Byun, D Hiler… - Environmental …, 2022 - iopscience.iop.org
Swamps are a highly significant wetland type in North America both in terms of areal extent
and their role in terrestrial carbon cycling. These wetlands, characterized by woody …

[HTML][HTML] Epigenetic modulation by apabetalone counters cytokine-driven acute phase response in vitro, in mice and in patients with cardiovascular disease

S Wasiak, D Gilham, E Daze, LM Tsujikawa… - Cardiovascular …, 2020 - hindawi.com
Chronic systemic inflammation contributes to cardiovascular disease (CVD) and correlates
with the abundance of acute phase response (APR) proteins in the liver and plasma. …

[HTML][HTML] Prolactin-inducible EDD E3 ubiquitin ligase promotes TORC1 signalling, anti-apoptotic protein expression, and drug resistance in breast cancer cells

TM MacDonald, LN Thomas, E Daze… - American Journal of …, 2019 - ncbi.nlm.nih.gov
Previously, we identified a prolactin (PRL)-inducible gene encoding EDD E3 ubiquitin
ligase in human breast cancer (BCa) cells. We reported that EDD binds the mTOR (TORC1)-…

Top 10 research priorities for early-stage colorectal cancer: a Canadian patient-oriented priority-setting partnership

…, G Laxdal, L Dundas, D Huband, E Daze… - … Open Access Journal, 2022 - cmajopen.ca
Background: Colorectal cancer, one of the most commonly diagnosed cancers, is now being
detected earlier and treatments are improving, which means that patients are living longer. …

Long-Term Carbon Accumulation in Temperate Swamp Soils: a Case Study from Greenock Swamp, Ontario, Canada

E Dazé, E Byun, SA Finkelstein - Wetlands, 2022 - Springer
Wetlands that develop peat are a globally significant pool of soil carbon. While some wetland
types such as bogs and fens are well characterized by the consistent development of …

Epigenetic BET reader inhibitor apabetalone (RVX-208) counters proinflammatory aortic gene expression in a diet induced obesity mouse model and in human …

S Wasiak, LM Tsujikawa, E Daze, D Gilham, SC Stotz… - Atherosclerosis, 2023 - Elsevier
Background and aims Obese patients are at risk for type 2 diabetes mellitus (T2DM) and
cardiovascular disease (CVD). A lipid-rich diet promotes arterial changes by inducing …

[HTML][HTML] The BET inhibitor apabetalone decreases neuroendothelial proinflammatory activation in vitro and in a mouse model of systemic inflammation

S Wasiak, L Fu, E Daze, D Gilham… - Translational …, 2023 - degruyter.com
Brain vascular inflammation is characterized by endothelial activation and immune cell
recruitment to the blood vessel wall, potentially causing a breach in the blood – brain barrier, …

[PDF][PDF] Hepatic Expression of C-Reactive Protein is Epigenetically Regulated by BET Proteins and Inhibited by Apabetalone (RVX-208) in vitro and in CVD Patients

S Wasiak, D Gilham, E Daze, C Halliday… - … and Vascular Biology, 2019 - resverlogix.com
Chronic inflammation contributes to cardiovascular disease (CVD) and is characterized by
elevated plasma levels of IL-6, IL-1β and C-reactive protein (CRP). CRP serves as a CVD …

[PDF][PDF] Apabetalone, a BET Bromodomain Inhibitor, Suppresses Inflammatory Mediators in Microglia and Vascular Endothelial Cells that Contribute to …

E Kulikowski, E Daze, S Wasiak, D Gilham… - 2018 - resverlogix.com
Results Apabetalone is an orally available small molecule in phase 3 trials for cardiovascular
disease (CVD). As an inhibitor of bromodomain and extraterminal domain (BET) proteins, …