Ultrapotent human antibodies protect against SARS-CoV-2 challenge via multiple mechanisms
…, B Guarino, S Bianchi, EJ Lauron, H Tucker, J Zhou… - Science, 2020 - science.org
Efficient therapeutic options are needed to control the spread of severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) that has caused more than 922,000 fatalities as of 13 …
syndrome coronavirus 2 (SARS-CoV-2) that has caused more than 922,000 fatalities as of 13 …
The dual function monoclonal antibodies VIR-7831 and VIR-7832 demonstrate potent in vitro and in vivo activity against SARS-CoV-2
VIR-7831 and VIR-7832 are dual action monoclonal antibodies (mAbs) targeting the spike
glycoprotein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). VIR-7831 …
glycoprotein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). VIR-7831 …
WDFY4 is required for cross-presentation in response to viral and tumor antigens
…, JT Davidson IV, CG Briseño, M Gargaro, EJ Lauron… - Science, 2018 - science.org
During the process of cross-presentation, viral or tumor-derived antigens are presented to
CD8 + T cells by Batf3-dependent CD8α + /XCR1 + classical dendritic cells (cDC1s). We …
CD8 + T cells by Batf3-dependent CD8α + /XCR1 + classical dendritic cells (cDC1s). We …
[HTML][HTML] Rhoptry Proteins ROP5 and ROP18 Are Major Murine Virulence Factors in Genetically Divergent South American Strains of Toxoplasma gondii
Toxoplasma gondii has evolved a number of strategies to evade immune responses in its
many hosts. Previous genetic mapping of crosses between clonal type 1, 2, and 3 strains of T. …
many hosts. Previous genetic mapping of crosses between clonal type 1, 2, and 3 strains of T. …
[HTML][HTML] Long-term correction of hemophilia B using adenoviral delivery of CRISPR/Cas9
CJ Stephens, EJ Lauron, E Kashentseva, ZH Lu… - Journal of controlled …, 2019 - Elsevier
Hemophilia B (HB) is a life-threatening inherited disease caused by mutations in the FIX
gene, leading to reduced protein function and abnormal blood clotting. Due to its monogenic …
gene, leading to reduced protein function and abnormal blood clotting. Due to its monogenic …
Coevolutionary patterns and diversification of avian malaria parasites in African sunbirds (Family Nectariniidae)
The coevolutionary relationships between avian malaria parasites and their hosts influence
the host specificity, geographical distribution and pathogenicity of these parasites. However, …
the host specificity, geographical distribution and pathogenicity of these parasites. However, …
HIF1α is required for NK cell metabolic adaptation during virus infection
Natural killer (NK) cells are essential for early protection against virus infection and must
metabolically adapt to the energy demands of activation. Here, we found upregulation of the …
metabolically adapt to the energy demands of activation. Here, we found upregulation of the …
[HTML][HTML] Glycosylation modulates arenavirus glycoprotein expression and function
CJ Bonhomme, AA Capul, EJ Lauron, LH Bederka… - Virology, 2011 - Elsevier
The glycoprotein of lymphocytic choriomeningitis virus (LCMV) contains nine potential N-linked
glycosylation sites. We investigated the function of these N-glycosylations by using …
glycosylation sites. We investigated the function of these N-glycosylations by using …
CD8+ T cell targeting of tumor antigens presented by HLA-E
…, T Beechwood, C Meyer, L Uebelhoer, EJ Lauron… - Science …, 2024 - science.org
The nonpolymorphic major histocompatibility complex E (MHC-E) molecule is up-regulated
on many cancer cells, thus contributing to immune evasion by engaging inhibitory NKG2A/…
on many cancer cells, thus contributing to immune evasion by engaging inhibitory NKG2A/…
A murine herpesvirus closely related to ubiquitous human herpesviruses causes T-cell depletion
SJ Patel, G Zhao, VR Penna, E Park, EJ Lauron… - Journal of …, 2017 - Am Soc Microbiol
The human roseoloviruses human herpesvirus 6A (HHV-6A), HHV-6B, and HHV-7 comprise
the Roseolovirus genus of the human Betaherpesvirinae subfamily. Infections with these …
the Roseolovirus genus of the human Betaherpesvirinae subfamily. Infections with these …
