User profiles for Edward T. Ryan

Edward T Ryan

Masschusetts General Hospital-Harvard University
Verified email at partners.org
Cited by 20074

[HTML][HTML] SARS-CoV-2 viral load is associated with increased disease severity and mortality

…, KT Flaherty, K Hall, M Dougan, ET Ryan… - Nature …, 2020 - nature.com
The relationship between SARS-CoV-2 viral load and risk of disease progression remains
largely undefined in coronavirus disease 2019 (COVID-19). Here, we quantify SARS-CoV-2 …

Persistence and decay of human antibody responses to the receptor binding domain of SARS-CoV-2 spike protein in COVID-19 patients

…, AG Schmidt, AS Azman, G Alter, ET Ryan… - Science …, 2020 - science.org
We measured plasma and/or serum antibody responses to the receptor-binding domain (RBD)
of the spike (S) protein of SARS-CoV-2 in 343 North American patients infected with …

Pediatric severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2): clinical presentation, infectivity, and immune responses

…, PH Lerou, JV Bonventre, GY Xu, ET Ryan… - The Journal of …, 2020 - Elsevier
Objectives As schools plan for re-opening, understanding the potential role children play in
the coronavirus infectious disease 2019 (COVID-19) pandemic and the factors that drive …

[PDF][PDF] Distinct early serological signatures track with SARS-CoV-2 survival

…, TJ Suscovich, C Linde, Y Cai, D Barouch, ET Ryan… - Immunity, 2020 - cell.com
As SARS-CoV-2 infections and death counts continue to rise, it remains unclear why some
individuals recover from infection, whereas others rapidly progress and die. Although the …

[HTML][HTML] Morbidity and mortality due to shigella and enterotoxigenic Escherichia coli diarrhoea: the Global Burden of Disease Study 1990–2016

…, F Qadri, MS Riddle, ET Ryan… - The Lancet infectious …, 2018 - thelancet.com
Background Shigella and enterotoxigenic Escherichia coli (ETEC) are bacterial pathogens
that are frequently associated with diarrhoeal disease, and are a significant cause of mortality …

[HTML][HTML] Compromised humoral functional evolution tracks with SARS-CoV-2 mortality

…, T Caradonna, AG Schmidt, Y Cai, H Streeck, ET Ryan… - Cell, 2020 - Elsevier
The urgent need for an effective SARS-CoV-2 vaccine has forced development to progress
in the absence of well-defined correlates of immunity. While neutralization has been linked to …

Clostridium difficile–associated diarrhea: a review

E Mylonakis, ET Ryan… - Archives of Internal …, 2001 - jamanetwork.com
Clostridium difficilecauses 300 000 to 3 000 000 cases of diarrhea and colitis in the United
States every year. Antibiotics most frequently associated with the infection are clindamycin, …

Phylogenetic analysis of SARS-CoV-2 in Boston highlights the impact of superspreading events

…, A Philippakis, M Burns, CM Brown, J Luban, ET Ryan… - Science, 2021 - science.org
INTRODUCTION We used genomic epidemiology to investigate the introduction and spread
of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the Boston area …

[HTML][HTML] Evaluation of SARS-CoV-2 serology assays reveals a range of test performance

…, MG Astudillo, BE Bernstein, JA Gelfand, ET Ryan… - Nature …, 2020 - nature.com
Appropriate use and interpretation of serological tests for assessments of severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) exposure, infection and potential immunity …

[HTML][HTML] Test performance evaluation of SARS-CoV-2 serological assays

…, BE Bernstein, JA Gelfand, ET Ryan… - Nature …, 2020 - ncbi.nlm.nih.gov
Appropriate use and interpretation of serological tests for assessments of SARS-CoV-2
exposure, infection and potential immunity require accurate assay performance data. We …