User profiles for Davide Corti

Davide Corti

SVP Antibody Research
Verified email at humabs.ch
Cited by 33894

Cross-neutralization of SARS-CoV-2 by a human monoclonal SARS-CoV antibody

…, MS Diamond, K Fink, D Veesler, D Corti - Nature, 2020 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a newly emerged
coronavirus that is responsible for the current pandemic of coronavirus disease 2019 (COVID-19), …

Exceptionally potent human monoclonal antibodies are effective for prophylaxis and treatment of tetanus in mice

M Pirazzini, A Grinzato, D Corti… - The Journal of …, 2021 - Am Soc Clin Investig
We used human monoclonal antibodies (humAbs) to study the mechanism of neuron
intoxication by tetanus neurotoxin and to evaluate these antibodies as a safe preventive and …

Broadly neutralizing antibodies overcome SARS-CoV-2 Omicron antigenic shift

…, A Lanzavecchia, G Snell, D Veesler, D Corti - Nature, 2022 - nature.com
The recently emerged SARS-CoV-2 Omicron variant encodes 37 amino acid substitutions in
the spike protein, 15 of which are in the receptor-binding domain (RBD), thereby raising …

Pemphigus autoantibodies generated through somatic mutations target the desmoglein-3 cis-interface

G Di Zenzo, G Di Lullo, D Corti… - The Journal of …, 2012 - Am Soc Clin Investig
Pemphigus vulgaris (PV) is an autoimmune blistering disease of skin and mucous membranes
caused by autoantibodies to the desmoglein (DSG) family proteins DSG3 and DSG1, …

Analysis of memory B cell responses and isolation of novel monoclonal antibodies with neutralizing breadth from HIV-1-infected individuals

D Corti, JPM Langedijk, A Hinz, MS Seaman… - PloS one, 2010 - journals.plos.org
Background The isolation of human monoclonal antibodies (mAbs) that neutralize a broad
spectrum of primary HIV-1 isolates and the characterization of the human neutralizing …

SARS-CoV-2 B. 1.617. 2 Delta variant replication and immune evasion

…, K Sato, S Bhatt, S Flaxman, LC James, D Corti… - Nature, 2021 - nature.com
The B.1.617.2 (Delta) variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
was first identified in the state of Maharashtra in late 2020 and spread throughout India, …

Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts infectivity and fusogenicity

…, AJ Fisher, MS Pizzuto, A de Marco, D Corti… - Nature, 2022 - nature.com
The SARS-CoV-2 Omicron BA.1 variant emerged in 2021 1 and has multiple mutations in its
spike protein 2 . Here we show that the spike protein of Omicron has a higher affinity for …

An infectious SARS-CoV-2 B. 1.1. 529 Omicron virus escapes neutralization by therapeutic monoclonal antibodies

…, JE Crowe Jr, LA Purcell, Y Kawaoka, D Corti… - Nature medicine, 2022 - nature.com
The emergence of the highly transmissible B.1.1.529 Omicron variant of severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) is concerning for antibody countermeasure …

[PDF][PDF] Mapping neutralizing and immunodominant sites on the SARS-CoV-2 spike receptor-binding domain by structure-guided high-resolution serology

…, F Sallusto, K Fink, HW Virgin, A Lanzavecchia, D Corti… - Cell, 2020 - cell.com
Analysis of the specificity and kinetics of neutralizing antibodies (nAbs) elicited by SARS-CoV-2
infection is crucial for understanding immune protection and identifying targets for …

Resistance of SARS-CoV-2 variants to neutralization by monoclonal and serum-derived polyclonal antibodies

…, D Pinto, DH Fremont, JE Crowe Jr, D Corti… - Nature medicine, 2021 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused the global
COVID-19 pandemic. Rapidly spreading SARS-CoV-2 variants may jeopardize newly …